Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination
about
Spartan/C1orf124 is important to prevent UV-induced mutagenesisCRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesisDVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damageHuman RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaksActivation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesisCharacterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage toleranceEvidence for a Rad18-independent frameshift mutagenesis pathway in human cell-free extractsRegulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway.RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replicationWerner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.Single cell analysis of human RAD18-dependent DNA post-replication repair by alkaline bromodeoxyuridine comet assay.The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCIRAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure.RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.Meiotic functions of RAD18.c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forksFunctional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forksRad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery.DNA-damage tolerance mediated by PCNA*Ub fusions in human cells is dependent on Rev1 but not Polη.Mutation analysis of Rad18 in human cancer cell lines and non small cell lung cancer tissues.Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA.Roles of sequential ubiquitination of PCNA in DNA-damage tolerance.REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks.Role of SUMO modification of human PCNA at stalled replication fork.RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1.Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting.DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategiesmiR-137 inhibits the proliferation of human non-small cell lung cancer cells by targeting SRC3.E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae.miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7.DNA repair protein Rad18 restricts LINE-1 mobility
P2860
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P2860
Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Human RAD18 is involved in S p ...... ithout PCNA monoubiquitination
@ast
Human RAD18 is involved in S p ...... ithout PCNA monoubiquitination
@en
type
label
Human RAD18 is involved in S p ...... ithout PCNA monoubiquitination
@ast
Human RAD18 is involved in S p ...... ithout PCNA monoubiquitination
@en
prefLabel
Human RAD18 is involved in S p ...... ithout PCNA monoubiquitination
@ast
Human RAD18 is involved in S p ...... ithout PCNA monoubiquitination
@en
P2093
P2860
P356
P1476
Human RAD18 is involved in S p ...... ithout PCNA monoubiquitination
@en
P2093
Hideo Tsuji
Hirokazu Inoue
Masahiko Mori
Masaru Yamaizumi
Naoko Shiomi
Satoshi Tateishi
Tadahiro Shiomi
Takashi Imai
P2860
P356
10.1093/NAR/GKL979
P407
P577
2006-12-07T00:00:00Z