A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. - Wikidata - wikimedia - TriplyDB

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors.

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors.

http://www.wikidata.org/entity/Q35649378

about

Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs Time to re-consider the meaning of BRAF V600E mutation in papillary thyroid carcinoma Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer Elucidating distinct roles for NF1 in melanomagenesis Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.Raf kinases in cancer-roles and therapeutic opportunities Copper is required for oncogenic BRAF signalling and tumorigenesis The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.p21 in cancer: intricate networks and multiple activities Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome.Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression.The landscape of BRAF transcript and protein variants in human cancer.Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.Senescent tumor cells lead the collective invasion in thyroid cancer.c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis.Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF.Mouse models of prostate cancer: picking the best model for the question.piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice.Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.Androgen receptor drives cellular senescence.Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.Stable cellular senescence is associated with persistent DDR activation Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.Clinical characteristics and course of 63 patients with BRAF mutant lung cancers.Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.Characterization of novel markers of senescence and their prognostic potential in cancer.Regulation of senescence in cancer and aging.Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins.Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas

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A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors.

http://www.wikidata.org/entity/Q35649378

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

A new mouse model to explore t ...... BRAFV600E-induced lung tumors.

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A new mouse model to explore t ...... BRAFV600E-induced lung tumors.

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type

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A new mouse model to explore t ...... BRAFV600E-induced lung tumors.

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A new mouse model to explore t ...... BRAFV600E-induced lung tumors.

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A new mouse model to explore t ...... BRAFV600E-induced lung tumors.

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A new mouse model to explore t ...... BRAFV600E-induced lung tumors.

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Genes & Development

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A new mouse model to explore t ...... BRAFV600E-induced lung tumors.

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David Dankort

http://www.w3.org/2001/XMLSchema#string

Elena Filenova

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Kirk Jones

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Manuel Collado

http://www.w3.org/2001/XMLSchema#string

Manuel Serrano

http://www.w3.org/2001/XMLSchema#string

Martin McMahon

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P2860

Back to the roots: the remarkable RAF oncogene story

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

Mutations of the BRAF gene in human cancer

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Identification of bronchioalveolar stem cells in normal lung and lung cancer

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Nucleolar Arf sequesters Mdm2 and activates p53

High frequency of BRAF mutations in nevi.

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.

Senescence of human fibroblasts induced by oncogenic Raf.

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379-384

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10.1101/GAD.1516407

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4

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21

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2007-02-13T00:00:00Z

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6506536

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17299132

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1804325

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