Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation. - Wikidata - wikimedia - TriplyDB

Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation.

Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation.

http://www.wikidata.org/entity/Q35650734

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Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation Dissecting the ER-associated degradation of a misfolded polytopic membrane protein.A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis Cleaning up in the endoplasmic reticulum: ubiquitin in charge The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones.Complement yourself: Transcomplementation rescues partially folded mutant proteins.The final moments of misfolded proteins en route to the proteasome.Applications of proteomic technologies for understanding the premature proteolysis of CFTR.A chaperone trap contributes to the onset of cystic fibrosis.Emergent properties of proteostasis in managing cystic fibrosis.The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation.ERp29 regulates DeltaF508 and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) trafficking to the plasma membrane in cystic fibrosis (CF) and non-CF epithelial cells.Saccharomyces cerivisiae as a model system for kidney disease: what can yeast tell us about renal function?Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation.Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae Assays to measure ER-associated degradation in yeast.Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease.FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability Hallmarks of therapeutic management of the cystic fibrosis functional landscape.Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27.Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations The endoplasmic reticulum-associated degradation pathways of budding yeast.Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation.Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway.Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation).The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel The activities and function of molecular chaperones in the endoplasmic reticulum.αB-Crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5.The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking ESCRT regulates surface expression of the Kir2.1 potassium channel.Glycosylation-directed quality control of protein folding.Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.

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P2860

Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation.

http://www.wikidata.org/entity/Q35650734

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Small heat-shock proteins sele ...... iculum-associated degradation.

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Small heat-shock proteins sele ...... iculum-associated degradation.

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type

label

Small heat-shock proteins sele ...... iculum-associated degradation.

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Small heat-shock proteins sele ...... iculum-associated degradation.

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prefLabel

Small heat-shock proteins sele ...... iculum-associated degradation.

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Small heat-shock proteins sele ...... iculum-associated degradation.

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MBC.E06-05-0458

P1433

Molecular Biology of the Cell

P1476

Small heat-shock proteins sele ...... iculum-associated degradation.

@en

P2093

Annette Ahner

http://www.w3.org/2001/XMLSchema#string

Hui Zhang

http://www.w3.org/2001/XMLSchema#string

Jeffrey L Brodsky

http://www.w3.org/2001/XMLSchema#string

Kunio Nakatsukasa

http://www.w3.org/2001/XMLSchema#string

Raymond A Frizzell

http://www.w3.org/2001/XMLSchema#string

P2860

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70

The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator

The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

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806-814

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scholarly article

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10.1091/MBC.E06-05-0458

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3

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18

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2006-12-20T00:00:00Z

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17182856

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endoplasmic reticulum

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1805084

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