Emergent properties of proteostasis in managing cystic fibrosis. - Wikidata - wikimedia - TriplyDB

Emergent properties of proteostasis in managing cystic fibrosis.

Emergent properties of proteostasis in managing cystic fibrosis.

http://www.wikidata.org/entity/Q34576386

about

Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis Expanding proteostasis by membrane trafficking networks Modulation of the maladaptive stress response to manage diseases of protein folding CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect Malfolded protein structure and proteostasis in lung diseases.Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.Using pharmacological chaperones to restore proteostasis Diffuse lung disease in children: summary of a scientific conference.A chaperone trap contributes to the onset of cystic fibrosis.The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis.Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability Resveratrol increases F508del-CFTR dependent salivary secretion in cystic fibrosis mice.Hallmarks of therapeutic management of the cystic fibrosis functional landscape.Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27.Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator.Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect.Unravelling druggable signalling networks that control F508del-CFTR proteostasis Restoration of NBD1 thermal stability is necessary and sufficient to correct ∆F508 CFTR folding and assembly CFTR: folding, misfolding and correcting the ΔF508 conformational defect.Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.Mechanism-based corrector combination restores ΔF508-CFTR folding and function.CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis.Diversity in the origins of proteostasis networks--a driver for protein function in evolution Repairing the basic defect in cystic fibrosis - one approach is not enough.Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR.Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis.Fixing cystic fibrosis by correcting CFTR domain assembly.Strategies for the etiological therapy of cystic fibrosis.Q-bodies monitor the quinary state of the protein fold.Emergent properties of microglia.Protein folding: salty sea regulators of cystic fibrosis.

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P2860

Emergent properties of proteostasis in managing cystic fibrosis.

http://www.wikidata.org/entity/Q34576386

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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Emergent properties of proteostasis in managing cystic fibrosis.

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CSHPERSPECT.A004499

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Cold Spring Harbor Perspectives in Biology

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Emergent properties of proteostasis in managing cystic fibrosis.

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Daniela M Roth

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Darren M Hutt

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William E Balch

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P2860

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

Chloride channels as drug targets.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

Protein homeostasis and aging: taking care of proteins from the cradle to the grave

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10.1101/CSHPERSPECT.A004499

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cystic fibrosis

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3039536

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