Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. - Wikidata - wikimedia - TriplyDB

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.

http://www.wikidata.org/entity/Q35661144

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Bile acids, obesity, and the metabolic syndrome Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice.Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice.Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats.Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats.Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes.A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism Pathogenesis of selective insulin resistance in isolated hepatocytes.Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene.The Role of Sirt1 in Bile Acid Regulation during Calorie Restriction in Mice The new biology of diabetes.Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats.Application of combined omics platforms to accelerate biomedical discovery in diabesity.Serum bile acids and GLP-1 decrease following telemetric induced weight loss: results of a randomized controlled trial.Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons.Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids.Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.Soaping up type 2 diabetes with bile acids?: the link between glucose and bile acid metabolism in humans tightens: quality matters!Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice.Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids.The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target?Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.Bile acids and bariatric surgery.Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner.Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption.FoxO1 is required for most of the metabolic and hormonal perturbations produced by hepatic insulin receptor deletion in male mice.Bile acids in glucose metabolism in health and disease.Adaptation of Intestinal and Bile Acid Physiology Accompany the Metabolic Benefits Following Ileal Interposition in the Rat.FoxO transcription factors are required for hepatic HDL-cholesterol clearance.Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences.Cross-talk among HMGA1 and FoxO1 in control of nuclear insulin signaling.Obesity diabetes and the role of bile acids in metabolism Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture

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P2860

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.

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Impaired generation of 12-hydr ...... n signaling with dyslipidemia.

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Impaired generation of 12-hydr ...... n signaling with dyslipidemia.

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Impaired generation of 12-hydr ...... n signaling with dyslipidemia.

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Cell Metabolism

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Impaired generation of 12-hydr ...... n signaling with dyslipidemia.

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Carrie L Welch

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Curtis D Klaassen

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P2860

Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns

Identification of a nuclear receptor for bile acids

Bile acids: natural ligands for an orphan nuclear receptor

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

Bile acids: regulation of synthesis

A simple method for the isolation and purification of total lipides from animal tissues

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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