Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis. - Wikidata - wikimedia - TriplyDB

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

http://www.wikidata.org/entity/Q35662004

about

Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants.Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Discovery of Novel Mycobacterial DNA Gyrase B Inhibitors: In Silico and In Vitro Biological Evaluation.New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.Resistance in tuberculosis: what do we know and where can we go?Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.News on therapeutic management of MDR-tuberculosis: a literature review.Recognizing drug targets using evolutionary information: implications for repurposing FDA-approved drugs against Mycobacterium tuberculosis H37Rv.Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents.Identification of novel gyrase B inhibitors as potential anti-TB drugs: homology modelling, hybrid virtual screening and molecular dynamics simulations.Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme-DNA complex and confer high enzyme processivity.α-pyrones and their hydroxylated analogs as promising scaffolds against Mycobacterium tuberculosis.Identification of promising DNA GyrB inhibitors for Tuberculosis using pharmacophore-based virtual screening, molecular docking and molecular dynamics studies.Assays, surrogates, and alternative technologies for a TB lead identification program targeting DNA gyrase ATPase.

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P2860

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

http://www.wikidata.org/entity/Q35662004

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2011年论文

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name

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

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Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

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Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

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Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

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Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

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Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

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P1433

Journal of Antimicrobial Chemotherapy

P1476

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

@en

P2093

Baojie Wan

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Haidan Guo

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Jeremiah P Malerich

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Karen Matsuyama

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Mariama C Maiga

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Peter B Madrid

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Shichun Lun

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Tran Tran

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William R Bishai

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P2860

Comprehensive identification of conditionally essential genes in mycobacteria

Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase

Slow elimination of multidrug-resistant tuberculosis

Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines

Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium

Delineating bacteriostatic and bactericidal targets in mycobacteria using IPTG inducible antisense expression

A high-throughput fluorescence polarization assay for inhibitors of gyrase B

Moxifloxacin versus ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial

Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis.

Sterilizing activities of fluoroquinolones against rifampin-tolerant populations of Mycobacterium tuberculosis.

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415-421

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scholarly article

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10.1093/JAC/DKR449

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2

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67

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Scott G. Franzblau

Sidharth Chopra

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2011-11-02T00:00:00Z

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51769506

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22052686

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Mycobacterium tuberculosis

P932

3254195

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