Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase
about
Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory proteinMycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxesMycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motionNew insights into fluoroquinolone resistance in Mycobacterium tuberculosis: functional genetic analysis of gyrA and gyrB mutationsImpact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistancePyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patientsPseudo-outbreak of pre-extensively drug-resistant (Pre-XDR) tuberculosis in Kinshasa: collateral damage caused by false detection of fluoroquinolone resistance by GenoType MTBDRsl.Docking studies on novel analogues of 8 methoxy fluoroquinolones against GyrA mutants of Mycobacterium tuberculosis.Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis.Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis.Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing.Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.Structure-based design of novel combinatorially generated NBTIs as potential DNA gyrase inhibitors against various Staphylococcus aureus mutant strains.Importance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistanceCrystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance.Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase ATPase domain.Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical IsolatesAssociation of gyrA/B mutations and resistance levels to fluoroquinolones in clinical isolates of Mycobacterium tuberculosis.Antibiotics as probes of biological complexity.Winning the arms race by improving drug discovery against mutating targets.Advances In Mycobacterium Tuberculosis Therapeutics Discovery Utlizing Structural Biology.Fighting an old disease with modern tools: characteristics and molecular detection methods of drug-resistant Mycobacterium tuberculosis.Double mutation in DNA gyrase confers moxifloxacin resistance and decreased fitness of Mycobacterium smegmatis.Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.Specific gyrA gene mutations predict poor treatment outcome in MDR-TB.Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyrase.Double Mutants in DNA Gyrase Lead to Ofloxacin Resistance in Mycobacterium tuberculosis.Insights into Pyrazinamidase and DNA Gyrase Protein Structures in Resistant and Susceptible Clinical Isolates of Mycobacterium tuberculosis.A novel resistance mutation in eccC5 of the ESX-5 secretion system confers ofloxacin resistance in Mycobacterium tuberculosis.Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTDPrevalence and Molecular Characterization of Second-Line Drugs Resistance among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Southwest of ChinaImpact of the E540V amino acid substitution in GyrB of Mycobacterium tuberculosis on quinolone resistanceAssociation of mutation patterns in gyrA/B genes and ofloxacin resistance levels in Mycobacterium tuberculosis isolates from East China in 2009.The role of Ca²⁺ in the activity of Mycobacterium tuberculosis DNA gyrase.Cluster-based molecular docking study for in silico identification of novel 6-fluoroquinolones as potential inhibitors against Mycobacterium tuberculosis.Strain Diversity and the Evolution of Antibiotic Resistance.Characterization of Ofloxacin Interaction with Mutated (A91V) Quinolone Resistance Determining Region of DNA Gyrase in Mycobacterium Leprae through Computational Simulation.
P2860
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P2860
Structural Insights into the Quinolone Resistance Mechanism of Mycobacterium tuberculosis DNA Gyrase
description
2010 nî lūn-bûn
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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@ast
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@en
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@nl
type
label
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@ast
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@en
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@nl
altLabel
Structural insights into the q ...... terium tuberculosis DNA gyrase
@en
prefLabel
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@ast
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@en
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@nl
P2093
P2860
P50
P1433
P1476
Structural Insights into the Q ...... terium tuberculosis DNA Gyrase
@en
P2093
Alexandra Aubry
Gwénaëlle André-Leroux
Vincent Jarlier
P2860
P304
P356
10.1371/JOURNAL.PONE.0012245
P407
P577
2010-08-18T00:00:00Z