Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane
about
A novel switch region regulates H-ras membrane orientation and signal outputDOC2B acts as a calcium switch and enhances vesicle fusionAnnexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosisRAS isoforms and mutations in cancer at a glanceGrb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancerRas plasma membrane signalling platformsSrc kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets.Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-ras diffusion and signaling.Water-membrane partition thermodynamics of an amphiphilic lipopeptide: an enthalpy-driven hydrophobic effect.Organization, dynamics, and segregation of Ras nanoclusters in membrane domains.Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.H-Ras forms dimers on membrane surfaces via a protein-protein interface.Particle image correlation spectroscopy (PICS): retrieving nanometer-scale correlations from high-density single-molecule position dataRas, an actor on many stages: posttranslational modifications, localization, and site-specified events.Signal integration by lipid-mediated spatial cross talk between Ras nanoclustersRas Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target.H-Ras nanocluster stability regulates the magnitude of MAPK signal outputIndividual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signalingTherapeutic intervention based on protein prenylation and associated modificationsAccurate quantification of diffusion and binding kinetics of non-integral membrane proteins by FRAP.Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membraneAlteration of EGFR spatiotemporal dynamics suppresses signal transduction.Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptorsRevealing conformational substates of lipidated N-Ras protein by pressure modulation.Sources of anomalous diffusion on cell membranes: a Monte Carlo studyPlasma membrane and nuclear localization of G protein coupled receptor kinase 6A.Ras trafficking, localization and compartmentalized signallingFleeting glimpses of lipid rafts: how biophysics is being used to track them.Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway.Formation and domain partitioning of H-ras peptide nanoclusters: effects of peptide concentration and lipid composition.Lipid rafts: contentious only from simplistic standpointsNonconventional trafficking of Ras associated with Ras signal organization.Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters.Electrostatic interactions positively regulate K-Ras nanocluster formation and functionFree energy profile of H-ras membrane anchor upon membrane insertion.Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins.H-ras protein in a bilayer: interaction and structure perturbationRas nanoclusters: molecular structure and assemblyK-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3.Rasosomes originate from the Golgi to dispense Ras signals.
P2860
Q24313439-1EF07309-02CD-4E94-9B52-479C29B27621Q24654645-5F2EC16D-2C17-423D-9B88-0783EBB14016Q27310437-B6FDF268-AB5D-45DC-868F-D839E7CA8258Q28070394-AB7755EB-1F04-49C6-ABD3-4D59DB7AA1D4Q28389726-F24F4F05-3996-42BF-8CDE-B31B1F3FD949Q28769530-FEB59F29-DC81-4E5C-9D7D-A92542E129EBQ30157893-08189E40-EDB3-497B-B519-F48506C25CB8Q30445383-56465BF3-F544-4EE2-8605-0390E7866E94Q30483693-A40F20F8-F6E1-4F0F-B391-5A752660E8A2Q30514229-BA533844-E186-4DDB-8BD6-D886C683C9ECQ30514480-8A325FBF-7CCD-4EE9-86FC-CEBACD137707Q30573159-FC0A50F4-533C-4628-92C7-BBFF1C7BF96FQ31073713-84ABBC73-600F-424E-A863-D061C373C504Q33351823-1B74B9A1-5A0D-4E6B-B6B5-D33395108BC0Q33623159-19A70203-B47F-44F2-8772-A81479FBDD05Q33646519-11698FD1-1F18-4F3F-A8C4-F9DB3AB81602Q33654281-341A9EC1-E52C-471D-8C5B-303B54F4E0FFQ33925229-7F7BFE09-D1A4-4514-B62D-1E5FA50686D8Q33943379-E692DAA5-EC4A-4A33-8FF7-3CEA3918E5AFQ33978808-09676719-72F1-40F3-97CD-84F0A3B03D67Q34233461-7A9C8160-A7D2-43E8-B746-CB6602B8C212Q34326437-64ECEC72-3382-4302-8FEC-ABB698F7AAF8Q35513856-2D6565D1-7707-4803-B4F5-901C8DE94AB6Q35673672-F1C0DA69-9BED-45FE-979C-BFF2CD580314Q35774474-72A4BAD3-D4C7-4796-9352-2FE4AAA490ACQ35942465-A12435EE-80FA-4F1E-BC81-3375B8AED26DQ36043314-619FC60A-94FC-4FC8-96CA-3388B832ACF2Q36278172-539698B0-1257-42AB-B0C2-FAD5CA7D0752Q36320736-E8741DE2-0F34-46C9-B30E-BF9AFF269249Q36341440-8B629B7B-92CD-480F-AEE7-726C43AC51C7Q36453789-0B953039-BC5C-4B54-8468-454319B7EF8BQ36528910-8E5A5BA5-F973-4D61-AFC1-94E449838119Q36536538-11499793-1982-4A4D-BDFE-862B3C0E1714Q36748140-75574EB5-1061-42B6-B5C7-9ADE6E524EECQ36786700-4462001F-74A8-4B86-A14F-DFC07E8197C1Q36846569-BE01562F-A765-432D-A453-A411189A16A7Q36864670-4C143932-6F6F-40BB-9B9C-FF8786B5AE4AQ36952890-9F84D05B-3E80-4BBE-A85B-E3B749D618A9Q36983120-541FF26F-30AE-44E5-A02D-BB120361A60AQ37073605-7F086D6F-0701-4986-A634-CE36F1F76538
P2860
Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Three separable domains regula ...... H-ras with the plasma membrane
@ast
Three separable domains regula ...... H-ras with the plasma membrane
@en
type
label
Three separable domains regula ...... H-ras with the plasma membrane
@ast
Three separable domains regula ...... H-ras with the plasma membrane
@en
prefLabel
Three separable domains regula ...... H-ras with the plasma membrane
@ast
Three separable domains regula ...... H-ras with the plasma membrane
@en
P2093
P2860
P1476
Three separable domains regula ...... H-ras with the plasma membrane
@en
P2093
Barak Rotblat
Cornelia Muncke
John F Hancock
Yoav I Henis
Yoel Kloog
P2860
P304
P356
10.1128/MCB.24.15.6799-6810.2004
P407
P577
2004-08-01T00:00:00Z