VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. - Wikidata - wikimedia - TriplyDB

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

http://www.wikidata.org/entity/Q35670733

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The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation Role of the Retromer Complex in Neurodegenerative Diseases β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration The retromer complex in development and disease Trafficking regulation of proteins in Alzheimer's disease The retromer complex - endosomal protein recycling and beyond The regulation and deregulation of Wnt signaling by PARK genes in health and disease Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration Dynamin 1 regulates amyloid generation through modulation of BACE-1 A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease VPS35 regulates cell surface recycling and signaling of dopamine receptor D1 Cargo trafficking in Alzheimer’s disease: the possible role of retromer Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability.Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis.VPS35, the Retromer Complex and Parkinson's Disease.High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.Retromer: a master conductor of endosome sorting.Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.Dysregulation of protein trafficking in neurodegeneration.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1 The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.

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P2860

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

http://www.wikidata.org/entity/Q35670733

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2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

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VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

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type

label

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

@ast

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

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prefLabel

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

@ast

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

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Journal of Cell Biology

P1476

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology

@en

P2093

Chengyong Shen

http://www.w3.org/2001/XMLSchema#string

Chun-Lei Wang

http://www.w3.org/2001/XMLSchema#string

Dae-hoon Lee

http://www.w3.org/2001/XMLSchema#string

Darrell Brann

http://www.w3.org/2001/XMLSchema#string

Fei Xiong

http://www.w3.org/2001/XMLSchema#string

Fu-Lei Tang

http://www.w3.org/2001/XMLSchema#string

Lei Wen

http://www.w3.org/2001/XMLSchema#string

Lin Mei

http://www.w3.org/2001/XMLSchema#string

Quan-Guang Zhang

http://www.w3.org/2001/XMLSchema#string

Riqiang Yan

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

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765-779

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scholarly article

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10.1083/JCB.201105109

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5

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195

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2011-11-21T00:00:00Z

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51820019

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22105352

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Alzheimer's disease

haploinsufficiency

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3257571

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