The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
about
Pain regulation by non-neuronal cells and inflammation.Repurposing a leukocyte elastase inhibitor for neuropathic pain.Nociceptor Sensitization Depends on Age and Pain Chronicity(1,2,3).Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice.Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic ReceptorsGene expression profiles reveal key pathways and genes associated with neuropathic pain in patients with spinal cord injury.Toward a Mechanism-Based Approach to Pain Diagnosis.Proteinases, Their Extracellular Targets, and Inflammatory Signaling.Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain.Breaking barriers to novel analgesic drug development.Pain in ankylosing spondylitis: a neuro-immune collaboration.Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.[EXPRESS] Immune System Involvement in Specific Pain Conditions.Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.Decreased alertness due to sleep loss increases pain sensitivity in mice.Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.Targeting novel mechanisms of pain in sickle cell disease.Altered expression of differential gene and lncRNA in the lower thoracic spinal cord on different time courses of experimental obstructive jaundice model accompanied with altered peripheral nociception in rats.AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trials.TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress.Signatures of Altered Gene Expression in Dorsal Root Ganglia of a Fabry Disease Mouse Model.Neutrophil elastase in the tumor microenvironment.Neuro-immune interactions in inflammation and host defense: Implications for transplantation.Mast cell-neural interactions contribute to pain and itch.CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.A modified immunofluorescence in situ hybridization method to detect long non-coding RNAs and proteins in frozen spinal cord sections.Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury.Preliminary investigation of the function of hsa_circ_0006215 in pancreatic cancer.Region-Resolved Quantitative Proteome Profiling Reveals Molecular Dynamics Associated With Chronic Pain in the PNS and Spinal Cord
P2860
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P2860
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The serine protease inhibitor ...... ll-derived leukocyte elastase.
@ast
The serine protease inhibitor ...... ll-derived leukocyte elastase.
@en
type
label
The serine protease inhibitor ...... ll-derived leukocyte elastase.
@ast
The serine protease inhibitor ...... ll-derived leukocyte elastase.
@en
prefLabel
The serine protease inhibitor ...... ll-derived leukocyte elastase.
@ast
The serine protease inhibitor ...... ll-derived leukocyte elastase.
@en
P2093
P2860
P50
P356
P1433
P1476
The serine protease inhibitor ...... ell-derived leukocyte elastase
@en
P2093
Alban Latremoliere
Bernd Arnold
Christian Njoo
Clifford J Woolf
David E Strochlic
Lucas Vicuña
Manuela Simonetti
Marcus A Mall
Michael Costigan
Priscilla Riva
P2860
P2888
P304
P356
10.1038/NM.3852
P407
P577
2015-04-27T00:00:00Z