High metastatic potential in mice inheriting a targeted p53 missense mutation.
about
Li-fraumeni syndromeContextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expressionSmall molecule compounds targeting the p53 pathway: are we finally making progress?The rebel angel: mutant p53 as the driving oncogene in breast cancer.Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinomaDMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarizationCharacterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers.Characteristics and survival of patients with advanced cancer and p53 mutations.Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 functionThe role of mutant p53 in human cancer.p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes.Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.Molecular characterization of serous ovarian carcinoma using a multigene next generation sequencing cancer panel approach.Assessing TP53 status in human tumours to evaluate clinical outcome.Crippling p53 activities via knock-in mutations in mouse models.Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation.Allele-specific p53 mutant reactivation.Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma.Loss of p53 and centrosome hyperamplification.Clinical relevance of gain-of-function mutations of p53 in high-grade serous ovarian carcinoma.Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomasHigh throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.TP53-Associated Pediatric Malignancies.Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.Mouse models with modified p53 sequences to study cancer and ageing.Primary neoplasms of bones in mice: retrospective study and review of literatureTransgenic and knockout mice models to reveal the functions of tumor suppressor genes.The p53R172H mutant does not enhance hepatocellular carcinoma development and progression.Translational approaches targeting the p53 pathway for anti-cancer therapy.Developing genetically engineered mouse models to study tumor suppression.Mutant p53: one name, many proteins.Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.Control of cell migration: a tumour suppressor function for p53?How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?P53 mutations in advanced cancers: clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy.The consequence of oncomorphic TP53 mutations in ovarian cancer.Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.One billion years of p53/p63/p73 evolution.
P2860
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P2860
High metastatic potential in mice inheriting a targeted p53 missense mutation.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
High metastatic potential in mice inheriting a targeted p53 missense mutation.
@ast
High metastatic potential in mice inheriting a targeted p53 missense mutation.
@en
type
label
High metastatic potential in mice inheriting a targeted p53 missense mutation.
@ast
High metastatic potential in mice inheriting a targeted p53 missense mutation.
@en
prefLabel
High metastatic potential in mice inheriting a targeted p53 missense mutation.
@ast
High metastatic potential in mice inheriting a targeted p53 missense mutation.
@en
P2093
P2860
P356
P1476
High metastatic potential in mice inheriting a targeted p53 missense mutation.
@en
P2093
El-Naggar AK
McDonnell TJ
Montes de Oca Luna R
P2860
P304
P356
10.1073/PNAS.97.8.4174
P407
P577
2000-04-01T00:00:00Z