RalA functions as an indispensable signal mediator for the nutrient-sensing system - Wikidata - wikimedia - TriplyDB

RalA functions as an indispensable signal mediator for the nutrient-sensing system

RalA functions as an indispensable signal mediator for the nutrient-sensing system

http://www.wikidata.org/entity/Q35676903

about

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly Regulation of TOR by small GTPases Spatial regulation of the mTORC1 system in amino acids sensing pathway Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony Leucine and mTORC1: a complex relationship Regulation of mTORC1 by PI3K signaling Role of amino acid transporters in amino acid sensing Nutrient regulation of the mTOR complex 1 signaling pathway Is REDD1 a Metabolic Éminence Grise?Ral GTPases: crucial mediators of exocytosis and tumourigenesis Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling TOR-dependent control of autophagy: biting the hand that feeds Auxin Signaling in Regulation of Plant Translation Reinitiation Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.Nutrient signaling to mTOR and cell growth.Direct Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells.Growing knowledge of the mTOR signaling network.Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1).Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect.FKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo.Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1).Negative regulation of the RalGAP complex by 14-3-3.Phosphatidic acid and lipid-sensing by mTOR Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons.Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation.Mammalian target of rapamycin and the kidney. I. The signaling pathway.p62: a versatile multitasker takes on cancer.A molecular rheostat at the interface of cancer and diabetes Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids.Key mediators of intracellular amino acids signaling to mTORC1 activation.RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy.FKBPs and the Akt/mTOR pathway ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding.

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P2860

RalA functions as an indispensable signal mediator for the nutrient-sensing system

http://www.wikidata.org/entity/Q35676903

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

RalA functions as an indispensable signal mediator for the nutrient-sensing system

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RalA functions as an indispensable signal mediator for the nutrient-sensing system

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type

label

RalA functions as an indispensable signal mediator for the nutrient-sensing system

@ast

RalA functions as an indispensable signal mediator for the nutrient-sensing system

@en

prefLabel

RalA functions as an indispensable signal mediator for the nutrient-sensing system

@ast

RalA functions as an indispensable signal mediator for the nutrient-sensing system

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P1433

Journal of Biological Chemistry

P1476

RalA functions as an indispensable signal mediator for the nutrient-sensing system

@en

P2093

Hiroshi Nishina

http://www.w3.org/2001/XMLSchema#string

Kentaro Hanada

http://www.w3.org/2001/XMLSchema#string

Makoto Murakami

http://www.w3.org/2001/XMLSchema#string

Masahiko Tanaka

http://www.w3.org/2001/XMLSchema#string

Tomohiko Maehama

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Yasunori Kanaho

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P2860

The small GTPase RalA targets filamin to induce filopodia

The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.

RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity

Dual requirement for a newly identified phosphorylation site in p70s6k

Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation

TOR signaling in growth and metabolism

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35053-35059

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scholarly article

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10.1074/JBC.M805822200

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50

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283

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18948269

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3259907

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