Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
about
A sucrose-derived scaffold for multimerization of bioactive peptidesMelanocortin-1 receptor structure and functional regulation.Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH.Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptorsEffects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs.The MC4 receptor and control of appetite.Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffoldAlpha-melanocyte stimulating hormone: production and degradation.Structure, function and regulation of the melanocortin receptors.Radiometallated peptides for molecular imaging and targeted therapy.Peptide scanning for studying structure-activity relationships in drug discovery.CNS drug targeting: have we travelled in right path?NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor.Molecular imaging probes derived from natural peptides.Adrenocorticotropic tumor cells transplanted into mouse embryos affect pancreatic histogenesis.Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity.Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation.Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.Modified melanocortin tetrapeptide Ac-His-dPhe-Arg-Trp-NH at the arginine side chain with ureas and thioureas.Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence.Semi-rigid tripeptide agonists of melanocortin receptors.Molecular Imaging and Radionuclide Therapy of Melanoma Targeting the Melanocortin 1 Receptor.Autoantibodies reactive to adrenocorticotropic hormone can alter cortisol secretion in both aggressive and nonaggressive humans.
P2860
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P2860
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
@ast
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
@en
type
label
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
@ast
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
@en
prefLabel
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
@ast
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
@en
P2860
P356
P1476
Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies.
@en
P2093
Carrie Haskell-Luevano
Jerry Ryan Holder
P2860
P304
P356
10.1002/MED.10064
P577
2004-05-01T00:00:00Z