The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.
about
The molecular basis of the Caskin1 and Mint1 interaction with CASKThe PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding modulemiR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cellsTiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatmentCellular signaling circuits interfaced with synthetic, post-translational, negating Boolean logic devicesTherapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancerTIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial CellsA functional and transcriptomic analysis of NET1 bioactivity in gastric cancer.CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cellsHeparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.miR-10b targets Tiam1: implications for Rac activation and carcinoma migrationDNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation.The role of fibroblast Tiam1 in tumor cell invasion and metastasisThe Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein.Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1Lentivirus-mediated silencing of Tiam1 gene influences multiple functions of a human colorectal cancer cell line.MicroRNA-377 suppresses cell proliferation and invasion by inhibiting TIAM1 expression in hepatocellular carcinomaRac signaling in breast cancer: a tale of GEFs and GAPs.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPaseProstaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.Clinicopathological implications of Tiam1 overexpression in invasive ductal carcinoma of the breastThe prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study.By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growthFriend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancerBiological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells.Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activationMechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors.Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.Tight junctions: a barrier to the initiation and progression of breast cancer?A gene trap knockout of the Tiam-1 protein results in malformation of the early embryonic brain.Characterization of a P-Rex1 gene signature in breast cancer cellsExpression of Tiam1 predicts lymph node metastasis and poor survival of lung adenocarcinoma patients.Protein-protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1.Overexpression of T lymphoma invasion and metastasis 1 predict renal cell carcinoma metastasis and overall patient survival.CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors.
P2860
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P2860
The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The role of the guanine nucleo ...... dhesion and tumor progression.
@ast
The role of the guanine nucleo ...... dhesion and tumor progression.
@en
type
label
The role of the guanine nucleo ...... dhesion and tumor progression.
@ast
The role of the guanine nucleo ...... dhesion and tumor progression.
@en
prefLabel
The role of the guanine nucleo ...... dhesion and tumor progression.
@ast
The role of the guanine nucleo ...... dhesion and tumor progression.
@en
P2093
P1476
The role of the guanine nucleo ...... dhesion and tumor progression.
@en
P2093
Gary E Gallick
Janet E Price
Lee-Su Kim
Meghan E Minard
P2860
P356
10.1023/B:BREA.0000018421.31632.E6
P407
P577
2004-03-01T00:00:00Z
P6179
1049791959