Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. - Wikidata - wikimedia - TriplyDB

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

http://www.wikidata.org/entity/Q34571293

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Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments Regulation and function of P-Rex family Rac-GEFs A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1 Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Novel insights into G protein and G protein-coupled receptor signaling in cancer PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cells BreakTrans: uncovering the genomic architecture of gene fusions P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site.Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells.RASAL2 activates RAC1 to promote triple-negative breast cancer progression Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Optimizing sparse sequencing of single cells for highly multiplex copy number profiling SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation Rac signaling in breast cancer: a tale of GEFs and GAPs.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth.Regulation of the mTOR-Rac1 axis in platelet function Targeting of Rac GTPases blocks the spread of intact human breast cancer.Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression.p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis Infectivity and insertional mutagenesis of endogenous retrovirus in autoimmune NZB and B/W mice.Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin.Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.

P2860

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P2860

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

http://www.wikidata.org/entity/Q34571293

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Identification of the Rac-GEF ...... bB signaling in breast cancer.

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Identification of the Rac-GEF ...... bB signaling in breast cancer.

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Identification of the Rac-GEF ...... bB signaling in breast cancer.

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type

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Identification of the Rac-GEF ...... bB signaling in breast cancer.

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Identification of the Rac-GEF ...... bB signaling in breast cancer.

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Identification of the Rac-GEF ...... bB signaling in breast cancer.

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prefLabel

Identification of the Rac-GEF ...... bB signaling in breast cancer.

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Identification of the Rac-GEF ...... bB signaling in breast cancer.

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Identification of the Rac-GEF ...... bB signaling in breast cancer.

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J.MOLCEL.2010.11.029

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Identification of the Rac-GEF ...... rbB signaling in breast cancer

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Andres Klein-Szanto

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Chengfeng Yang

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Hiroshi Yagi

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Hongbin Wang

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Jeffrey L Benovic

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Jiansong Luo

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John M Busillo

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Marcelo G Kazanietz

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Maria Soledad Sosa

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Ramon E Parsons

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Involvement of chemokine receptors in breast cancer metastasis

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

Rho GTPases: biochemistry and biology

Untangling the ErbB signalling network

The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells

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877-892

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scholarly article

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10.1016/J.MOLCEL.2010.11.029

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6

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40

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J. Silvio Gutkind

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2010-12-01T00:00:00Z

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49697140

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21172654

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