Small-molecule proteostasis regulators for protein conformational diseases. - Wikidata - wikimedia - TriplyDB

Small-molecule proteostasis regulators for protein conformational diseases.

Small-molecule proteostasis regulators for protein conformational diseases.

http://www.wikidata.org/entity/Q35683088

about

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives Expanding proteostasis by membrane trafficking networks Protein homeostasis as a therapeutic target for diseases of protein conformation Keep your heart in shape: molecular chaperone networks for treating heart disease Huntington's disease: underlying molecular mechanisms and emerging concepts Modulation of the maladaptive stress response to manage diseases of protein folding Dysferlin-peptides reallocate mutated dysferlin thereby restoring function The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation The hallmarks of aging A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model.Protein homeostasis disorders of key enzymes of amino acids metabolism: mutation-induced protein kinetic destabilization and new therapeutic strategies.Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models.Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase.Getting folded: chaperone proteins in muscle development, maintenance and disease.Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin.A chaperone trap contributes to the onset of cystic fibrosis.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition.Pharmacological Correctors of Mutant CFTR Mistrafficking.The biology of proteostasis in aging and disease.Regulation of the mammalian heat shock factor 1.DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise.Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts The unpredictability of prolonged activation of stress response pathways.Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration.Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity.Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans Targeting protein aggregation for the treatment of degenerative diseases

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P2860

Small-molecule proteostasis regulators for protein conformational diseases.

http://www.wikidata.org/entity/Q35683088

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name

Small-molecule proteostasis regulators for protein conformational diseases.

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Small-molecule proteostasis regulators for protein conformational diseases.

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Small-molecule proteostasis regulators for protein conformational diseases.

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Small-molecule proteostasis regulators for protein conformational diseases.

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Small-molecule proteostasis regulators for protein conformational diseases.

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Small-molecule proteostasis regulators for protein conformational diseases.

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Nature Chemical Biology

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Small-molecule proteostasis regulators for protein conformational diseases.

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P2093

Barbara Calamini

http://www.w3.org/2001/XMLSchema#string

Bradley D Tait

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Dan Garza

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Darren M Hutt

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Franck Madoux

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Maria Catarina Silva

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Monica A Chalfant

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Peter Hodder

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Richard I Morimoto

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S Adrian Saldanha

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P2860

Signal integration in the endoplasmic reticulum unfolded protein response

Adapting proteostasis for disease intervention

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

Biological and chemical approaches to diseases of proteostasis deficiency

HSP90 and the chaperoning of cancer

Pathways of chaperone-mediated protein folding in the cytosol

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

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185-196

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scholarly article

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10.1038/NCHEMBIO.763

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2

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8

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2011-12-25T00:00:00Z

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51924443

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22198733

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3262058

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