Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
about
Allosteric activation of the protein kinase PDK1 with low molecular weight compoundsMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistancePKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysisThe mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CCharacterization of a PDK1 homologue from the moss Physcomitrella patensPDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.Substrate and docking interactions in serine/threonine protein kinasesPhosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.Regulation of mRNA translation in renal physiology and disease.Steady-state kinetic mechanism of PDK1.Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse developmentPfIRR Interacts with HrIGF-I and Activates the MAP-kinase and PI3-kinase Signaling Pathways to Regulate Glycogen Metabolism in Pinctada fucata.Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survivalLoss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C epsilon phosphorylation.Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase.Role of AGC kinases in plant growth and stress responses.Evolutionary Adaptations of Plant AGC Kinases: From Light Signaling to Cell Polarity RegulationExpression of 3-phosphoinositide-dependent protein kinase 1 in colorectal cancer as a potential therapeutic target.The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts.Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.The T-loop extension of the tomato protein kinase AvrPto-dependent Pto-interacting protein 3 (Adi3) directs nuclear localization for suppression of plant cell death.Sch9 regulates intracellular protein ubiquitination by controlling stress responses.Adi3 is a Pdk1-interacting AGC kinase that negatively regulates plant cell deathYeast 3-phosphoinositide-dependent protein kinase-1 (PDK1) orthologs Pkh1-3 differentially regulate phosphorylation of protein kinase A (PKA) and the protein kinase B (PKB)/S6K ortholog Sch9.Loss of post-translational modification sites in disease.Two Pdk1 phosphorylation sites on the plant cell death suppressor Adi3 contribute to substrate phosphorylation.Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis.Fer kinase limits neutrophil chemotaxis toward end target chemoattractants.Targeting PDK1 for Chemosensitization of Cancer Cells.SCA14 mutation V138E leads to partly unfolded PKCγ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization.Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.
P2860
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P2860
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
@ast
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
@en
type
label
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
@ast
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
@en
prefLabel
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
@ast
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
@en
P1476
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.
@en
P2093
Ricardo M Biondi
P304
P356
10.1016/J.TIBS.2004.01.005
P577
2004-03-01T00:00:00Z