The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
about
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor modelmTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideSREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthmTORC2 phosphorylates protein kinase Cζ to regulate its stability and activityPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12Protein kinases and phosphatases in the control of cell fateFat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolismSpatial regulation of the mTORC1 system in amino acids sensing pathwayTargeting mTOR for the treatment of AML. New agents and new directionsThe substrates and binding partners of protein kinase CepsilonEmerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer developmentRegulation of protein kinase C inactivation by Fas-associated protein with death domainMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyNesfatin-1 action in the brain increases insulin sensitivity through Akt/AMPK/TORC2 pathway in diet-induced insulin resistanceTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyUbiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 responsemTOR: from growth signal integration to cancer, diabetes and ageingCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1mTOR signaling: at the crossroads of plasticity, memory and diseaseA complex interplay between Akt, TSC2 and the two mTOR complexesmTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceAnticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effectSirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular EffectsTargeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?Dynamics and Membrane Interactions of Protein Kinase CMolecular characterizations of glioblastoma, targeted therapy, and clinical results to dateThe atypical PKCs in inflammation: NF-κB and beyondFOXO transcription factors throughout T cell biologyRegulation of mTORC1 by PI3K signalingEnhancing integrin function by VEGF/neuropilin signaling: implications for tumor biologyUbl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branchingRictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1Crystal Structure and Allosteric Activation of Protein Kinase C βIIUtilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraintsProtein kinase C mechanisms that contribute to cardiac remodellingmTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesisInhibition of mTOR signaling reduces PELP1-mediated tumor growth and therapy resistanceRegulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networksProtein kinase C: poised to signalBSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation
P2860
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P2860
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
description
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Juli 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/07/23)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/07/23)
@nl
наукова стаття, опублікована в липні 2008
@uk
مقالة علمية (نشرت في 23-7-2008)
@ar
name
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@ast
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@en
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@nl
type
label
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@ast
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@en
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@nl
prefLabel
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@ast
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@en
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
The mammalian target of rapamy ...... ty of Akt and protein kinase C
@en
P2093
Adam Lazorchak
Carolyn Lowry
Christine Gould
Nelyn Soto
Pumin Zhang
Robert Q. Miao
Valeria Facchinetti
P2860
P304
P3181
P356
10.1038/EMBOJ.2008.120
P407
P577
2008-07-23T00:00:00Z