Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
about
Novel drugs that target the metabolic reprogramming in renal cell cancerThe sweet trap in tumors: aerobic glycolysis and potential targets for therapyTargeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implicationRestoration of mitochondria function as a target for cancer therapyIncreasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular AscorbateDichloroacetate affects proliferation but not apoptosis in canine mammary cell lines.Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in childrenDual-targeting of aberrant glucose metabolism in glioblastomaInvestigational cancer drugs targeting cell metabolism in clinical development.Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid TumorsDifferential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetateSMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma.Targeting of two aspects of metabolism in breast cancer treatment.Targeting glucose metabolism in cancer: new class of agents for loco-regional and systemic therapy of liver cancer and beyond?Clinical development of cancer therapeutics that target metabolism.Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapyMulti-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth.Mitochondrial pyruvate carrier function and cancer metabolism.Metabolic control of epigenetics in cancer.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic TreatmentsDichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer PropertiesThe influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.Long-term stabilization of metastatic melanoma with sodium dichloroacetateOncogenic regulation of tumor metabolic reprogramming.Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition.Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Cell death-based treatment of neuroblastoma.Therapy for Chronic Myelomonocytic Leukemia in a New Era.Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model.AKT-independent activation of p38 MAP kinase promotes vascular calcification.Actionable Metabolic Pathways in Heart Failure and Cancer—Lessons From Cancer Cell Metabolism.
P2860
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P2860
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
@ast
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
@en
type
label
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
@ast
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
@en
prefLabel
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
@ast
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
@en
P2093
P2860
P1476
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
@en
P2093
A L Shroads
D A Wagner
E M Dunbar
J J Shuster
J R Forder
P W Stacpoole
P2860
P2888
P304
P356
10.1007/S10637-013-0047-4
P577
2013-12-03T00:00:00Z