Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors. - Wikidata - wikimedia - TriplyDB

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

http://www.wikidata.org/entity/Q35684292

about

Novel drugs that target the metabolic reprogramming in renal cell cancer The sweet trap in tumors: aerobic glycolysis and potential targets for therapy Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication Restoration of mitochondria function as a target for cancer therapy Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines.Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children Dual-targeting of aberrant glucose metabolism in glioblastoma Investigational cancer drugs targeting cell metabolism in clinical development.Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma.Targeting of two aspects of metabolism in breast cancer treatment.Targeting glucose metabolism in cancer: new class of agents for loco-regional and systemic therapy of liver cancer and beyond?Clinical development of cancer therapeutics that target metabolism.Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth.Mitochondrial pyruvate carrier function and cancer metabolism.Metabolic control of epigenetics in cancer.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.Long-term stabilization of metastatic melanoma with sodium dichloroacetate Oncogenic regulation of tumor metabolic reprogramming.Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition.Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Cell death-based treatment of neuroblastoma.Therapy for Chronic Myelomonocytic Leukemia in a New Era.Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model.AKT-independent activation of p38 MAP kinase promotes vascular calcification.Actionable Metabolic Pathways in Heart Failure and Cancer—Lessons From Cancer Cell Metabolism.

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P2860

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

http://www.wikidata.org/entity/Q35684292

description

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2013年论文

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name

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

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type

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

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Investigational New Drugs

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.

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P2093

A L Shroads

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A Lew

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B S Coats

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D A Wagner

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E M Dunbar

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J R Forder

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P W Stacpoole

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T Langaee

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P2860

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes

Understanding the Warburg effect: the metabolic requirements of cell proliferation

A New Statistical Method for Haplotype Reconstruction from Population Data

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

Metabolic modulation of glioblastoma with dichloroacetate

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3

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dichloroacetate

phase I clinical trial

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4455946

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