Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
about
Sphingolipids: a potential molecular approach to treat allergic inflammationDiscovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonistsDiscovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeThe sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticityGlycocalyx and its involvement in clinical pathophysiologiesSphingosine 1-phosphate receptor agonists: a patent review (2010-2012)Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive AntagonismAbluminal stimulation of sphingosine 1-phosphate receptors 1 and 3 promotes and stabilizes endothelial sprout formation.Drugging sphingosine kinases.Characterization of a sphingosine 1-phosphate receptor antagonist prodrugStereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsSphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.An evolutionarily conserved arginine is essential for Tre1 G protein-coupled receptor function during germ cell migration in Drosophila melanogasterTreatment with a sphingosine analog does not alter the outcome of a persistent virus infection.A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigrationFunctional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome.Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungsUnderstanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage.Sphingosine-1-phosphate and immune regulation: trafficking and beyondFingolimod for relapsing multiple sclerosis: an update.Predictability of peripheral lymphocyte reduction of novel S1P1 agonists by in vitro GPCR signaling profile.Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytesPharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor.Central Autonomic Dysfunction Delays Recovery of Fingolimod Induced Heart Rate Slowing.A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.The outs and the ins of sphingosine-1-phosphate in immunityThe selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro ModelNovel selective allosteric and bitopic ligands for the S1P(3) receptor.Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injuryIdentification of a metabolizing enzyme in human kidney by proteomic correlation profiling.
P2860
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P2860
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Chemical modulators of sphingo ...... oriented therapeutic molecules
@ast
Chemical modulators of sphingo ...... oriented therapeutic molecules
@en
type
label
Chemical modulators of sphingo ...... oriented therapeutic molecules
@ast
Chemical modulators of sphingo ...... oriented therapeutic molecules
@en
prefLabel
Chemical modulators of sphingo ...... oriented therapeutic molecules
@ast
Chemical modulators of sphingo ...... oriented therapeutic molecules
@en
P2860
P356
P1476
Chemical modulators of sphingo ...... oriented therapeutic molecules
@en
P2093
David Marsolais
Hugh Rosen
P2860
P2888
P304
P356
10.1038/NRD2356
P577
2009-03-20T00:00:00Z