The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine.
about
PrimPol, an archaic primase/polymerase operating in human cellsMitochondrial DNA replication and disease: insights from DNA polymerase γ mutationsThe fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesGenetics of primary ovarian insufficiency: new developments and opportunitiesDNA polymerase γ and disease: what we have learned from yeastMitochondrial DNA damage and its consequences for mitochondrial gene expressionOxidative stress is not a major contributor to somatic mitochondrial DNA mutationsSubstitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP To Be Inserted opposite 7,8-Dihydro-8-oxoguanine,Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA PolymeraseAn analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitorsMMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variantsAnalysis of Translesion DNA Synthesis by the Mitochondrial DNA Polymerase γMitochondrial genome maintenance in health and disease.mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiaeDefects of mitochondrial DNA replication.Overexpression of DNA polymerase zeta reduces the mitochondrial mutability caused by pathological mutations in DNA polymerase gamma in yeast.Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi.Molecular dissection of the domain architecture and catalytic activities of human PrimPol.Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegansEffect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity.Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.Depletion of mitochondrial DNA in fibroblast cultures from patients with POLG1 mutations is a consequence of catalytic mutations.Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γMitochondria as a target of environmental toxicants.Human mitochondrial DNA replication machinery and disease.DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations.Mitochondrial DNA exhibits resistance to induced point and deletion mutations.Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction.Novel therapeutic targets in depression and anxiety: antioxidants as a candidate treatment.The importance of mitochondria in age-related and inherited eye disorders.POLG1-related and other "mitochondrial Parkinsonisms": an overview.Mouse models of DNA polymerases.Inherited mitochondrial genomic instability and chemical exposures.Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.DNA polymerase beta participates in mitochondrial DNA repair.A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?Analysis of mutant DNA polymerase gamma in patients with mitochondrial DNA depletion.Clinical Reasoning: A 58-year-old man with progressive ptosis and walking difficulty.
P2860
Q24339480-5E71D115-7C67-4E19-82A8-3D58A418BE86Q24612561-D421FCED-4CF8-42DD-98F7-D1400101F7F3Q24630867-B261AC31-5185-4716-9E01-A4A8B181A886Q26798895-2886B770-2FFA-4ADE-A44B-CB01DB447D9BQ26825324-0FACF324-4560-406C-8F44-AEFAB1CE8051Q27001150-0CEF68D5-5BFF-473F-980D-022B016F9DDDQ27319050-FA4EA570-E3F0-4D41-A166-2ED87F2ACAC3Q27660750-AF2AFF93-3A36-473C-925A-5E3C4488198CQ27675203-AF288C8D-2C44-406D-9827-DB85A5E82DABQ28474361-07F2B429-7DC9-43FD-85CA-D3E29CDB1E53Q28544021-E5E0B76E-1AD6-4E59-BABD-C698F35FA0F1Q28828743-87EEBC2D-2326-4906-862B-BE9475A62068Q33821051-930BEFDE-6A7F-4141-8772-69166CB01220Q33832860-9ABDB0EF-62A7-4F4C-8645-5F35D31F1D1FQ34098312-E9AB697C-8E93-4F93-B350-455EB31CFECDQ34217894-69E9E119-08C7-4502-A2BC-FBB4989DC191Q34372632-099E5081-131E-43D1-95B2-BE049BDCFE51Q34412816-011C99A2-34F4-4967-A353-F22C6D911635Q34653802-CA629D60-E282-46A2-A4E4-CD0CC431EFCEQ36053570-8E550127-A7A7-4051-9216-4509954A36B1Q36626862-23FCCA4B-6A44-485C-8362-CF1FBA83A64FQ36633152-5828B6C9-48C7-4A72-882F-96A2130CA9EEQ36794013-43AF1AB6-70B7-467D-9FD0-455D05D3CE3AQ36850288-C5D3DF00-7C1A-4357-BD22-4D587CB2D69DQ36956066-CB2BC55B-5674-4B33-862C-156C6A23B869Q37322422-0FFD687E-3461-4E85-A1E5-DEF35E1A0BECQ37325936-F8FF5719-2DD8-4ED6-9F92-3A160C4532BDQ37336970-BD037054-198C-4193-810C-D3DE9BC03231Q37425966-BAFDFCF4-F1E3-4D62-84E2-FE4190CFF5F6Q37661357-3E695FA1-0A38-4038-8CE3-AC3E1A772015Q37786972-529EBE2A-8B26-48E6-A35C-A32BCDF2E9FBQ37827400-19821131-863B-46EF-BC47-5C29050D3873Q38045848-A6D3CAEC-FDFB-43B4-9CC0-AC4D7A56A36AQ38649815-1379CFF8-8ED8-4543-8341-C33937A3680EQ41940970-303BAA69-4048-40FA-8AED-0017B230E909Q50051893-BABB3C0F-5C1F-4D55-B16F-6684F85C8F46Q50347029-8D734C8E-FDF4-4CC6-BB34-C570C66D48B4Q51760977-3F0AA1BB-2E9E-47C5-B02A-D2524EB080EAQ54798811-7622ABFA-B1BC-41BF-A1B3-12972B3496DEQ55407764-2477E2FA-05B7-4578-BAA0-9CF45E180354
P2860
The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The DNA polymerase gamma Y955C ...... hydro-8-oxo-2'-deoxyguanosine.
@ast
The DNA polymerase gamma Y955C ...... hydro-8-oxo-2'-deoxyguanosine.
@en
type
label
The DNA polymerase gamma Y955C ...... hydro-8-oxo-2'-deoxyguanosine.
@ast
The DNA polymerase gamma Y955C ...... hydro-8-oxo-2'-deoxyguanosine.
@en
prefLabel
The DNA polymerase gamma Y955C ...... hydro-8-oxo-2'-deoxyguanosine.
@ast
The DNA polymerase gamma Y955C ...... hydro-8-oxo-2'-deoxyguanosine.
@en
P2860
P356
P1476
The DNA polymerase gamma Y955C ...... hydro-8-oxo-2'-deoxyguanosine.
@en
P2093
Maria A Graziewicz
William C Copeland
P2860
P304
P356
10.1093/HMG/DDM227
P577
2007-08-27T00:00:00Z