Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. - Wikidata - wikimedia - TriplyDB

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

http://www.wikidata.org/entity/Q35705307

about

IDH1 and IDH2 mutations in gliomas Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas Mitochondrial metabolic remodeling in response to genetic and environmental perturbations The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets Diagnostic and therapeutic biomarkers in pancreaticobiliary malignancy An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma Targeted Therapy in Biliary Tract Cancers Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma Cholangiocarcinoma Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies Novel therapeutic targets of tumor metabolism IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives Maffucci syndrome and neoplasms: a case report and review of the literature Metabolic consequences of oncogenic IDH mutations 2-Hydoxyglutarate: D/Riving Pathology in gLiomaS Molecular Markers in Low-Grade Glioma-Toward Tumor Reclassification Role of mitochondrial dysfunction in cancer progression Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets.Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing.Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas The potential role of comprehensive genomic profiling to guide targeted therapy for patients with biliary cancer.Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups.Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma Metabolic requirements for the maintenance of self-renewing stem cells.Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery Molecular pathogenesis of cholangiocarcinoma.A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.Oncometabolites: linking altered metabolism with cancer.5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.Prospective enterprise-level molecular genotyping of a cohort of cancer patients.A fatal case of primary basaloid squamous cell carcinoma in the intrahepatic bile ducts.

P2860

Q24561928-440DB8A7-1E27-406B-B7B3-1CEDE861923F Q24610836-6241F19B-03AA-480E-8A05-160AF7E0F140 Q26747718-EB20A463-811A-494E-987A-19E7005CB9B6 Q26751224-1D6BFD05-0AE0-4411-95E1-0A477A7ED914 Q26767120-B6A0A781-61B0-49E9-9712-4EDA114B8BD7 Q26784091-CA915747-F6DB-4D5F-8033-591C5FEB3EFC Q26798443-C32E8D83-5B85-4524-8387-7FCDA912668D Q26852049-55F925A0-F46F-4F30-B270-60C02FDF5214 Q26995506-DDD0D12D-9926-434B-AAEA-DE558245ED2F Q27001694-C890D546-4FEA-45BF-85C1-3DC044EB20C7 Q27002547-A9058310-F42C-41C1-B7E6-42ED39E50A32 Q27005930-001FB8D2-12D6-4BB6-9FE7-CB01B0418D77 Q27692015-75A6A43F-16F0-4568-A3AD-F54C4EF862E7 Q27852141-2DD99D92-7FF9-4C69-BD15-79A4BCD2A132 Q27852856-A6A72F8C-8D33-4F3A-9AD8-F605227DC342 Q28066926-A4EEDA18-5A53-4C6E-B28D-1C57C5455D95 Q28069937-EE4BC606-2693-413B-A91E-A19C461641FF Q28082949-31CE4953-E677-442B-B2A7-CBD8DD20BC9A Q28087807-53DEC735-415A-45D8-9638-0AD4E8D881AB Q28383205-7F00073B-0CFF-4EA1-A7A4-A2303EE861D0 Q28829644-3805AFF8-F26C-4003-9836-CEABB9C33204 Q30252418-62473975-A7A9-4426-9E02-D4507337F277 Q30405398-5147BF3D-3D8A-4DB5-99FA-71237D162E2D Q30664676-DE378DA5-8337-4B06-9339-520BCED4D91F Q32173000-B1733B39-5FB2-4DC4-A696-EF8B12DA1198 Q33556447-AF144CB1-3347-49BE-B484-08CC8555D769 Q33581027-E0785D04-72D2-49B3-A874-AA53B4D2D662 Q33656860-6FEDD264-7DF3-40B2-AF3F-B4FF5125C79C Q33699608-E422EC9D-8B05-4688-A12E-6B99281BFED5 Q33757122-F4760E3F-632E-43B8-AF9D-153FC2FA6D85 Q33763540-702D5142-3343-4F0E-8933-4EE8E2A09F3A Q33893346-FADF648A-EB29-4BD3-AF77-71F36A58BFEF Q33936179-7F2A7910-A633-41D8-B3CC-E5AE4E317E5D Q34002347-36F66067-59CD-4FE2-9513-01D536D98D5F Q34065560-0F0BB04E-7BAB-4000-95F1-A720BEA9D373 Q34342259-DAFD6BF5-5387-4455-92B9-5BF92435A0E1 Q34368256-33181BE8-5546-438C-863E-DE6930D73524 Q34374136-8F1C610F-0EE7-49B8-B772-E0007F3AF244 Q34409739-22E37A5C-9589-4BA7-BA6B-3D70268CC534 Q34454193-127EC1A8-AB4F-4A31-A7A0-E2DC1024AE8B

P2860

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

http://www.wikidata.org/entity/Q35705307

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Frequent mutation of isocitrat ...... broad-based tumor genotyping.

@ast

Frequent mutation of isocitrat ...... broad-based tumor genotyping.

@en

type

label

Frequent mutation of isocitrat ...... broad-based tumor genotyping.

@ast

Frequent mutation of isocitrat ...... broad-based tumor genotyping.

@en

prefLabel

Frequent mutation of isocitrat ...... broad-based tumor genotyping.

@ast

Frequent mutation of isocitrat ...... broad-based tumor genotyping.

@en

P1433

Q35705307-4E529847-C0F6-453B-8A54-4EEBB70AA641

P1476

Q35705307-887E2C94-74AB-4A8A-92B6-3AD3E089F1F6

P2093

Q35705307-0A3FA4F2-150A-40CD-9C53-6E1B028FE2D4

Q35705307-0E4DC997-A6C0-46C4-9467-4BCFCE6D485D

Q35705307-15E28F9A-DD2E-45DC-BAA5-80F06172885E

Q35705307-196B3312-F941-48DE-AA89-685C77ECC594

Q35705307-33E87DCF-2807-4A95-AFE2-360C08C425AA

Q35705307-341ABCB7-ED48-4604-8608-4E9517A8066B

Q35705307-34B68812-3220-4446-8A1D-49DF27498952

Q35705307-5ABEF07A-98D4-49C2-A601-7B3CD7FFFCD4

Q35705307-5E45F70D-D797-4152-B342-0752588DDBAC

Q35705307-6FB09452-5ECF-473B-A8EE-E56C08455FD5

P2860

Q35705307-11C464A4-2FAB-4A34-A8D4-6C7618984F6E

Q35705307-12324FDD-5640-421F-B706-F46158E340C0

Q35705307-17594797-40FA-4590-90CB-E9FD3F81C30C

Q35705307-2B9F8ABB-ED8E-44BD-9C2D-790E1C835316

Q35705307-2C66D15E-649C-4C62-8AC2-29F2A9638929

Q35705307-2D573B91-A1FF-4F3C-A817-98270B6E04F1

Q35705307-339BB5AE-83F5-47E3-8430-6052FB2C8D76

Q35705307-36ACE8EF-C96C-4CC9-BE0E-A37C1F70BEF3

Q35705307-3B9C6A09-2FDF-4D80-AFE0-2911BF89A753

Q35705307-3CE6BEE7-E236-4F60-8CAB-D596CC054877

P304

Q35705307-FD9F05F2-6D8E-4F7D-A233-391FE4D34423

P31

Q35705307-A93F00C8-767F-4F6D-AE82-2EC4F6358330

P356

Q35705307-E44A15AC-B0D6-42C4-9B45-E43E9A59E402

P433

Q35705307-E07405B2-CDDB-44BB-8927-7CD3C84074E8

P478

Q35705307-E0127849-DA6D-49C4-B95B-50EC336602BD

P577

Q35705307-576290F0-1DDE-4054-9746-618897E24CB6

P5875

Q35705307-45F9A2C5-F0C1-4BFA-A143-41EB21B1BF68

P698

Q35705307-3698231B-3543-4938-86CC-5D59D9C6DC98

P921

Q35705307-A194343E-E84A-48E0-AC41-62E9E637E252

P932

Q35705307-600C15A0-9A28-4C3F-8781-25E26E7A8B1A

P356

THEONCOLOGIST.2011-0386

P1433

P1476

Frequent mutation of isocitrat ...... broad-based tumor genotyping.

@en

P2093

A John Iafrate

http://www.w3.org/2001/XMLSchema#string

Andrew X Zhu

http://www.w3.org/2001/XMLSchema#string

Aram F Hezel

http://www.w3.org/2001/XMLSchema#string

Darrell R Borger

http://www.w3.org/2001/XMLSchema#string

David P Ryan

http://www.w3.org/2001/XMLSchema#string

David P Schenkein

http://www.w3.org/2001/XMLSchema#string

Dora Dias-Santagata

http://www.w3.org/2001/XMLSchema#string

Eunice L Kwak

http://www.w3.org/2001/XMLSchema#string

Hannah M Liebman

http://www.w3.org/2001/XMLSchema#string

Hector U Lopez

http://www.w3.org/2001/XMLSchema#string

P2860

Global cancer statistics

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

Molecular origins of cancer: Molecular basis of colorectal cancer

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

An integrated genomic analysis of human glioblastoma multiforme

IDH1 and IDH2 mutations in gliomas

P304

72-79

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1634/THEONCOLOGIST.2011-0386

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

17

http://www.w3.org/2001/XMLSchema#string

P577

2011-12-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51898860

http://www.w3.org/2001/XMLSchema#string

P698

22180306

http://www.w3.org/2001/XMLSchema#string

P921

cholangiocarcinoma

P932

3267826

http://www.w3.org/2001/XMLSchema#string