Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
about
Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotidesAncient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.STING: infection, inflammation and cancerLinking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosusAre human endogenous retroviruses pathogenic? An approach to testing the hypothesisThe enemy within: endogenous retroelements and autoimmune diseaseCytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNATLRs and interferons: a central paradigm in autoimmunityRPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNASpecies-specific detection of the antiviral small-molecule compound CMA by STINGStructure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAAStructural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGASInnate immune detection of microbial nucleic acids.Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and AutoinflammationmiRNAs in the Pathogenesis of Systemic Lupus ErythematosusMutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signatureThe dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunityApoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunityMammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrityTLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathwaysThe SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAsMouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunityNLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STINGAutoimmunity: homeostasis of innate immunity gone awry.DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.Type I interferon in the pathogenesis of lupus.Activation of the STING adaptor attenuates experimental autoimmune encephalitis.Spontaneous activation of RNA-sensing pathways in autoimmune disease.Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis.The SKIV2L RNA exosome limits activation of the RIG-I-like receptorscGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.IFNαR signaling in effector but not regulatory T cells is required for immune dysregulation during type I IFN-dependent inflammatory disease.Activated STING in a vascular and pulmonary syndromeTrex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genesSTING recognition of cytoplasmic DNA instigates cellular defense.Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.Intrinsic self-DNA triggers inflammatory disease dependent on STING.Aicardi-Goutières syndrome and the type I interferonopathies.IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
P2860
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P2860
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Autoimmunity initiates in nonh ...... n-dependent autoimmune disease
@ast
Autoimmunity initiates in nonh ...... n-dependent autoimmune disease
@en
type
label
Autoimmunity initiates in nonh ...... n-dependent autoimmune disease
@ast
Autoimmunity initiates in nonh ...... n-dependent autoimmune disease
@en
prefLabel
Autoimmunity initiates in nonh ...... n-dependent autoimmune disease
@ast
Autoimmunity initiates in nonh ...... n-dependent autoimmune disease
@en
P2093
P2860
P1433
P1476
Autoimmunity initiates in nonh ...... n-dependent autoimmune disease
@en
P2093
Daniel B Stetson
Glen N Barber
Keith B Elkon
Piper Treuting
Yueh-Ming Loo
P2860
P304
P356
10.1016/J.IMMUNI.2011.11.018
P407
P577
2012-01-01T00:00:00Z