Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
about
DAXX is a new AIRE-interacting proteinDeaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetesAire and T cell developmentTranscriptional regulation by AIRE: molecular mechanisms of central toleranceOvarian autoimmune disease: clinical concepts and animal modelsLymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patientsAn autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouse.Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cellsChagasic thymic atrophy does not affect negative selection but results in the export of activated CD4+CD8+ T cells in severe forms of human disease.The immune response to melanoma is limited by thymic selection of self-antigensClues to immune tolerance: the monogenic autoimmune syndromesThymus-specific deletion of insulin induces autoimmune diabetes.Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection.A role for the IkappaB family member Bcl-3 in the control of central immunologic toleranceReduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism.B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients.Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1.Primer: immunity and autoimmunityThe variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity.An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.Monogenic autoimmune diseases: insights into self-tolerance.BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.Physiopathology of idiopathic nephrotic syndrome: lessons from glucocorticoids and epigenetic perspectives.Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.Transcriptional programs that control expression of the autoimmune regulator gene Aire.Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1.Border control: Anatomical origins of the thymus medulla.Clock-dependent and independent transcriptional control of the two isoforms from the mouse Rorgamma gene.AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.Twenty Years of AIRE.Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4
P2860
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P2860
Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity
description
2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
@zh-hk
2007年論文
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2007年論文
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2007年论文
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2007年论文
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2007年论文
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name
Loss of Aire-dependent thymic ...... rs it a target of autoimmunity
@ast
Loss of Aire-dependent thymic ...... rs it a target of autoimmunity
@en
type
label
Loss of Aire-dependent thymic ...... rs it a target of autoimmunity
@ast
Loss of Aire-dependent thymic ...... rs it a target of autoimmunity
@en
prefLabel
Loss of Aire-dependent thymic ...... rs it a target of autoimmunity
@ast
Loss of Aire-dependent thymic ...... rs it a target of autoimmunity
@en
P2093
P2860
P356
P1476
Loss of Aire-dependent thymic ...... rs it a target of autoimmunity
@en
P2093
Christophe Benoist
Diane Mathis
Hidde Ploegh
Irina Gavanescu
P2860
P304
P356
10.1073/PNAS.0700259104
P407
P577
2007-03-06T00:00:00Z