Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
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Rho GTPases in hematopoiesis and hemopathiesInhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemiaMitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesisTransforming human blood stem and progenitor cells: a new way forward in leukemia modeling.Rac guanosine triphosphatases represent a potential target in AMLDown-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferationELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse.The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemiaBmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells.IRF-4 suppresses BCR/ABL transformation of myeloid cells in a DNA binding-independent manner.miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML)RalA, a GTPase targeted by miR-181a, promotes transformation and progression by activating the Ras-related signaling pathway in chronic myelogenous leukemia.Deregulation of Rho GTPases in cancerTargeting the leukemic stem cell: the Holy Grail of leukemia therapyThe diverse roles of Rac signaling in tumorigenesisTargeting phosphatidylinositol 3-kinase signaling in acute myelogenous leukemia.The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increased of persistence of Rac activation in chronic myeloid leukemia.Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction.Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia.BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance.Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.Helicobacter pylori-induced gastric mucosal TGF-α ectodomain shedding and EGFR transactivation involves Rac1/p38 MAPK-dependent TACE activation.Mtss1 is a critical epigenetically regulated tumor suppressor in CML.ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia.Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.
P2860
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P2860
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
@ast
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
@en
type
label
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
@ast
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
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prefLabel
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
@ast
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
@en
P2093
P2860
P356
P1433
P1476
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
@en
P2093
D A Williams
E K Thomas
J A Cancelas
P2860
P2888
P304
P356
10.1038/LEU.2008.71
P577
2008-03-20T00:00:00Z