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The signaling involving in autophagy machinery in keratinocytes and therapeutic approaches for skin diseasesPI3K and AKT: Unfaithful Partners in CancerIn situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12CMacropinocytosis Exploitation by Cancers and Cancer TherapeuticsNovel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPasesROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: study in African-American and Caucasian prostate cancer modelsRac1 Regulates Endometrial Secretory Function to Control Placental DevelopmentOncogene-like induction of cellular invasion from centrosome amplification.Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo.A novel interaction between the SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1 engulfment and cell motility 1 (ELMO1) promotes Rac1 activation and cell motility.MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activationSimultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters.Topological and functional properties of the small GTPases protein interaction network.The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.RASAL2 activates RAC1 to promote triple-negative breast cancer progressionMicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603.Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types.Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancersCharacterization of EHop-016, novel small molecule inhibitor of Rac GTPaseSmooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity.Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.Redox regulation of Rac1 by thiol oxidation.Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.Deregulation of Rho GTPases in cancerTumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour.F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation.Targeting Rho GTPase signaling for cancer therapy.Growth factor transduction pathways: paradigm of anti-neoplastic targeted therapy.Integrins and epithelial cell polarity.Janus-faces of NME-oncoprotein interactions.ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signallingRac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitorsAutophagy in cancer metastasis.The Neuregulin-Rac-MKK7 pathway regulates antagonistic c-jun/Krox20 expression in Schwann cell dedifferentiation.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 May 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The diverse roles of Rac signaling in tumorigenesis
@en
The diverse roles of Rac signaling in tumorigenesis.
@nl
type
label
The diverse roles of Rac signaling in tumorigenesis
@en
The diverse roles of Rac signaling in tumorigenesis.
@nl
prefLabel
The diverse roles of Rac signaling in tumorigenesis
@en
The diverse roles of Rac signaling in tumorigenesis.
@nl
P2093
P2860
P356
P1433
P1476
The diverse roles of Rac signaling in tumorigenesis
@en
P2093
Angeliki Malliri
Helen J Whalley
Natalie A Mack
Sonia Castillo-Lluva
P2860
P304
P356
10.4161/CC.10.10.15612
P577
2011-05-15T00:00:00Z