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Intracellular transport of recombinant adeno-associated virus vectors.

Intracellular transport of recombinant adeno-associated virus vectors.

http://www.wikidata.org/entity/Q35734826

about

Predictors of hepatitis B cure using gene therapy to deliver DNA cleavage enzymes: a mathematical modeling approach Gene therapy delivery systems for enhancing viral and nonviral vectors for cardiac diseases: current concepts and future applications.Myocardial gene transfer: routes and devices for regulation of transgene expression by modulation of cellular permeability In vivo dynamics of AAV-mediated gene delivery to sensory neurons of the trigeminal ganglia Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno-Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor-β Gene Delivery.Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them.Reduced phenotypic severity following adeno-associated virus-mediated Fmr1 gene delivery in fragile X mice.Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors.Vector platforms for gene therapy of inherited retinopathies.Optimization of the capsid of recombinant adeno-associated virus 2 (AAV2) vectors: the final threshold?Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction.A comparative analysis of constitutive promoters located in adeno-associated viral vectors.Cystic Fibrosis Gene Therapy in the UK and Elsewhere.Effectiveness of gene delivery systems for pluripotent and differentiated cells.The SUMOylation Pathway Restricts Gene Transduction by Adeno-Associated Viruses An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8.Productive life cycle of adeno-associated virus serotype 2 in the complete absence of a conventional polyadenylation signal.Glycan binding avidity determines the systemic fate of adeno-associated virus type 9.A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord.Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids.Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution.Adeno-associated virus capsid antigen presentation is dependent on endosomal escape.Mucopolysaccharidosis IIIB confers enhanced neonatal intracranial transduction by AAV8 but not by 5, 9 or rh10 Disruption of Microtubules Post-Virus Entry Enhances Adeno-Associated Virus Vector Transduction.Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo.An essential receptor for adeno-associated virus infection.Transgene expression in target-defined neuron populations mediated by retrograde infection with adeno-associated viral vectors Recombinant adeno-associated virus vectors in the treatment of rare diseases.Impact of age and vector construct on striatal and nigral transgene expression.Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure.Bacteriophages as vehicles for gene delivery into mammalian cells: prospects and problems.Viral Vector-Mediated Antisense Therapy for Genetic Diseases.Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy.Gene therapy and imaging in preclinical and clinical oncology: recent developments in therapy and theranostics.Systemic delivery of adeno-associated viral vectors.Preferred transduction with AAV8 and AAV9 via thalamic administration in the MPS IIIB model: A comparison of four rAAV serotypes.A chemical switch for controlling viral infectivity.

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Intracellular transport of recombinant adeno-associated virus vectors.

http://www.wikidata.org/entity/Q35734826

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Intracellular transport of recombinant adeno-associated virus vectors.

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Retrograde transport pathways utilised by viruses and protein toxins

T RANSPORT B ETWEEN THE C ELL N UCLEUS AND THE C YTOPLASM

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism.

Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors

Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection

Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells.

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