A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.
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OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamiliesRenal drug transporters and their significance in drug-drug interactionsThe organic anion transporter (OAT) family: a systems biology perspectiveEvolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence MotifsThe large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerizationPutative transmembrane domain 12 of the human organic anion transporter hOAT1 determines transporter stability and maturation efficiency.Drug uptake systems in liver and kidney: a historic perspectiveFunctional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4).SV2 regulates neurotransmitter release via multiple mechanisms.Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors.Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3)Functional significance of conserved cysteines in the human organic cation transporter 2.Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines.Cisplatin-induced downregulation of OCTN2 affects carnitine wastingFuture directions for drug transporter modelling.Ins and outs of major facilitator superfamily antiporters.Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family membersMATE1 has an external COOH terminus, consistent with a 13-helix topology.Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition.Renal transport of organic anions and cations.Synaptic vesicle protein 2A: basic facts and role in synaptic function.Mechanism of high affinity inhibition of the human urate transporter URAT1A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid.Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout.Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport.Alanine scanning mutagenesis of a high-affinity nitrate transporter highlights the requirement for glycine and asparagine residues in the two nitrate signature motifs.From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity.Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) familyMolecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity
P2860
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P2860
A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A three-dimensional model of h ...... uired for substrate transport.
@ast
A three-dimensional model of h ...... uired for substrate transport.
@en
type
label
A three-dimensional model of h ...... uired for substrate transport.
@ast
A three-dimensional model of h ...... uired for substrate transport.
@en
prefLabel
A three-dimensional model of h ...... uired for substrate transport.
@ast
A three-dimensional model of h ...... uired for substrate transport.
@en
P2093
P2860
P356
P1476
A three-dimensional model of h ...... uired for substrate transport.
@en
P2093
Jennifer L Perry
John B Pritchard
Laura A Hall
Neetu Dembla-Rajpal
P2860
P304
38071-38079
P356
10.1074/JBC.M608834200
P407
P577
2006-10-11T00:00:00Z