New pathway links γ-secretase to inflammation and memory while sparing notch.

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The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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P1476

New pathway links γ-secretase to inflammation and memory while sparing notch.

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Brandon Wustman

http://www.w3.org/2001/XMLSchema#string

Sam Gandy

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals

The secretases: enzymes with therapeutic potential in Alzheimer disease.

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene.

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scholarly article

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10.1002/ANA.22310

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2011-01-01T00:00:00Z

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49797286

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21280069

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3274708

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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P2860

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New pathway links γ-secretase to inflammation and memory while sparing notch.

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