Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex. - Wikidata - wikimedia - TriplyDB

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex.

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex.

http://www.wikidata.org/entity/Q35744526

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CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover Targeting and transport: how microtubules control focal adhesion dynamics Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration Invadopodia in context FAK in cancer: mechanistic findings and clinical applications Stromal fibroblasts facilitate cancer cell invasion by a novel invadopodia-independent matrix degradation process.Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes Cortactin as a target for FAK in the regulation of focal adhesion dynamics Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton.NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion Spatiotemporal regulation of Src and its substrates at invadosomes Integrated proteomics identified up-regulated focal adhesion-mediated proteins in human squamous cell carcinoma in an orthotopic murine model.Phosphoinositide 3-kinase p85beta regulates invadopodium formation.FAK competes for Src to promote migration against invasion in melanoma cells.SRChing for the substrates of Src.N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.Adhesion rings surround invadopodia and promote maturation.Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion.Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.Invadosomes in their natural habitat.Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion.LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis Breaking away: matrix remodeling from the leading edge.Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion.Importance of RhoGTPases in formation, characteristics, and functions of invadosomes.Fluorescence live cell imaging.Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis Membrane-Type 1 Matrix Metalloproteinase Downregulates Fibroblast Growth Factor-2 Binding to the Cell Surface and Intracellular Signaling.CD26 expression on T-anaplastic large cell lymphoma (ALCL) line Karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion Fenretinide Perturbs Focal Adhesion Kinase in Premalignant and Malignant Human Oral Keratinocytes. Fenretinide's Chemopreventive Mechanisms Include ECM Interactions.Nestin depletion induces melanoma matrix metalloproteinases and invasion WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion DPP in the matrix mediates cell adhesion but is not restricted to stickiness: a tale of signaling.Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome.Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.Regulation of invadopodia by mechanical signaling.

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P2860

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex.

http://www.wikidata.org/entity/Q35744526

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Mark A McNiven

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Yu Wang

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P2860

Integrin signalling: a new Cas(t) of characters enters the stage

Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors

Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells

Differential regulation of cell motility and invasion by FAK

Assembly and biological role of podosomes and invadopodia

The matrix corroded: podosomes and invadopodia in extracellular matrix degradation

p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

New functions for the matrix metalloproteinases in cancer progression

Focal adhesion kinase: in command and control of cell motility

Taking cell-matrix adhesions to the third dimension

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375-385

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10.1083/JCB.201105153

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