Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
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The Prodrug Approach: A Successful Tool for Improving Drug SolubilityNovel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic miceMolecular Approaches to Screen Bioactive Compounds from Endophytic FungiOridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive responseDiscovery and development of natural product oridonin-inspired anticancer agentsSmall compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myelomaIdentification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cellsOridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signalingA polymethoxyflavone from Laggera pterodonta induces apoptosis in imatinib-resistant K562R cells via activation of the intrinsic apoptosis pathwaySynthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agentsSynergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia.Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent mannerOridonin inhibits breast cancer growth and metastasis through blocking the Notch signaling.Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-mycOridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.Oridonin: targeting programmed cell death pathways as an anti-tumour agent.ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoidsOridonin inhibits hepatic stellate cell proliferation and fibrogenesis.Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway.Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviolEffector caspases and leukemiaCancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.Anti-cancer natural products isolated from chinese medicinal herbsOridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling.Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis.Antiangiogenic effects of oridonin.Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathwayJaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway.Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia.Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cellsNovel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubilityInvestigation of the anti‑asthmatic activity of Oridonin on a mouse model of asthma.Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma.Inhalable oridonin-loaded poly(lactic-co-glycolic)acid large porous microparticles for in situ treatment of primary non-small cell lung cancer.Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues.Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathwayInduction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species.JAK inhibitors suppress t(8;21) fusion protein-induced leukemia.
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P2860
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Oridonin, a diterpenoid extrac ...... leukemia in vitro and in vivo.
@ast
Oridonin, a diterpenoid extrac ...... leukemia in vitro and in vivo.
@en
type
label
Oridonin, a diterpenoid extrac ...... leukemia in vitro and in vivo.
@ast
Oridonin, a diterpenoid extrac ...... leukemia in vitro and in vivo.
@en
prefLabel
Oridonin, a diterpenoid extrac ...... leukemia in vitro and in vivo.
@ast
Oridonin, a diterpenoid extrac ...... leukemia in vitro and in vivo.
@en
P2093
P2860
P1433
P1476
Oridonin, a diterpenoid extrac ...... leukemia in vitro and in vivo.
@en
P2093
Dong-Er Zhang
Feng-Xiang Zhang
Guang-Biao Zhou
Long-Jun Gu
P2860
P304
P356
10.1182/BLOOD-2006-06-032250
P407
P577
2006-12-29T00:00:00Z