Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation - Wikidata - wikimedia - TriplyDB

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

http://www.wikidata.org/entity/Q28348865

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Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter CBFbeta is a facultative Runx partner in the sea urchin embryo.Core Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic Opportunities Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase The Runx3 distal transcript encodes an additional transcriptional activation domain Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1 CBFbeta is critical for AML1-ETO and TEL-AML1 activity.A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii).PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.A novel inherited mutation of the transcription factor RUNX1 causes thrombocytopenia and may predispose to acute myeloid leukaemia.Integrative analysis of RUNX1 downstream pathways and target genes.Runx expression is mitogenic and mutually linked to Wnt activity in blastula-stage sea urchin embryos Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Core binding factor β (CBFβ) is retained in the midbody during cytokinesis Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.ERM/ETV5 and RUNX1/AML1 expression in endometrioid adenocarcinomas of endometrium and association with neoplastic progression.BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Common themes in the pathogenesis of acute myeloid leukemia.Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).Core-binding factor acute myeloid leukemia: Heterogeneity, monitoring, and therapy.Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.Disruption of differentiation in human cancer: AML shows the way.Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway

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Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

http://www.wikidata.org/entity/Q28348865

description

2001 nî lūn-bûn

@nan

2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

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2001年論文

@zh-tw

2001年论文

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name

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@ast

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@en

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@nl

type

label

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@ast

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@en

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@nl

prefLabel

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@ast

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@en

Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

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The EMBO Journal

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Dimerization with PEBP2beta pr ...... roteasome-mediated degradation

@en

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Huang G

http://www.w3.org/2001/XMLSchema#string

Ito K

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Ito Y

http://www.w3.org/2001/XMLSchema#string

Shigesada K

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Wee HJ

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Yokomizo T

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P2860

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells

Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

The ubiquitin system

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

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232774168

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11179217

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ubiquitin-proteasome system

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145428

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