MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
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Interleukin-24 and its receptorsMechanism of Action and Applications of Interleukin 24 in ImmunotherapyA novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosisRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells.MDA-7/IL-24 as a cancer therapeutic: from bench to bedside.MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer.IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.The development of MDA-7/IL-24 as a cancer therapeuticRecombinant adenovirus IL-24-Bax promotes apoptosis of hepatocellular carcinoma cells in vitro and in vivo.Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.IL-24 is expressed during wound repair and inhibits TGFalpha-induced migration and proliferation of keratinocytesmda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineMDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo.IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells.Molecular Mechanisms Governing IL-24 Gene Expression.Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cellsInsulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancer.Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing.IL-24: a classic cytokine and/or a potential cure for cancer?HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1.The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells.Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities.Inhibitory Effect and Mechanism of Mesenchymal Stem Cells Cultured in 3D System on Hepatoma Cells HepG2.IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas.Cell-penetrating and endoplasmic reticulum-locating TAT-IL-24-KDEL fusion protein induces tumor apoptosis.Optimisation of the mRNA secondary structure to improve the expression of interleukin-24 (IL-24) in Escherichia coli.Expression, purification, and characterization of RGD-mda-7, a His-tagged mda-7/IL-24 mutant protein.Influence of pro- and anti-inflammatory cytokines in Th1 polarization after allogeneic stimulation.Recombinant human interleukin-24 suppresses gastric carcinoma cell growth in vitro and in vivo.Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24.MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity.The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer.Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells.Melanoma differentiation-associated gene-7 (mda-7)/interleukin (IL)-24 induces anticancer immunity in a syngeneic murine model.MDA-7/IL-24 inhibits cell survival by inducing apoptosis in nasopharyngeal carcinoma.MicroRNA-205 directly regulates the tumor suppressor, interleukin-24, in human KB oral cancer cells.Enhanced antitumor efficacy of a novel oncolytic adenovirus combined with temozolomide in the treatment of melanoma in vivo.mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members.Melanoma differentiation-associated gene-7 suppresses human gastric cancer cell invasion and migration.
P2860
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P2860
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
@ast
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
@en
type
label
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
@ast
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
@en
prefLabel
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
@ast
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.
@en
P2093
P1476
MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family
@en
P2093
Abner M Mhashilkar
Aysegul A Sahin
Elizabeth A Grimm
Heng-Yin Yang
Jack A Roth
John B Mumm
Julie Ellerhorst
Kelly K Hunt
Kerry L Fuson
Nancy Poìndexter
P304
P356
10.1016/J.INTIMP.2004.01.017
P577
2004-05-01T00:00:00Z