Absence of perforin expression confers axonal protection despite demyelination.
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CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosisA single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelinationOrgan-specific protective role of NKT cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain.RNase L mediated protection from virus induced demyelination.Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice.Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouseTransgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosisEnhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis.Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes.A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal miceDeletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosisCD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelinationEnhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.A monoclonal natural human IgM protects axons in the absence of remyelinationPathoetiology of multiple sclerosis: are we barking up the wrong tree?Axons are injured by antigen-specific CD8(+) T cells through a MHC class I- and granzyme B-dependent mechanism.Profile of Circulatory Metabolites in a Relapsing-remitting Animal Model of Multiple Sclerosis using Global Metabolomics.The relevance of animal models in multiple sclerosis research.Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.Brainstem 1H nuclear magnetic resonance (NMR) spectroscopy: marker of demyelination and repair in spinal cord.Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination.CD8(+) T cells in multiple sclerosis.Multiple sclerosis: experimental models and reality.Axonal degeneration in multiple sclerosis: defining therapeutic targets by identifying the causes of pathology.Promoting return of function in multiple sclerosis: An integrated approach.Immunity and inflammation in neurodegenerative diseases.Morphological and functional characterization of leech circulating blood cells: role in immunity and neural repair.Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons.
P2860
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P2860
Absence of perforin expression confers axonal protection despite demyelination.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Absence of perforin expression confers axonal protection despite demyelination.
@ast
Absence of perforin expression confers axonal protection despite demyelination.
@en
type
label
Absence of perforin expression confers axonal protection despite demyelination.
@ast
Absence of perforin expression confers axonal protection despite demyelination.
@en
prefLabel
Absence of perforin expression confers axonal protection despite demyelination.
@ast
Absence of perforin expression confers axonal protection despite demyelination.
@en
P2093
P2860
P50
P1476
Absence of perforin expression confers axonal protection despite demyelination
@en
P2093
Charles L Howe
Jaimie D Adelson
Moses Rodriguez
P2860
P304
P356
10.1016/J.NBD.2006.10.001
P577
2006-11-16T00:00:00Z