ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.
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The ANGPTL3-4-8 model, a molecular mechanism for triglyceride traffickingThe role of ANGPTL3 in controlling lipoprotein metabolismHepatic ANGPTL3 regulates adipose tissue energy homeostasis.Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion.Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism.Inactivating Variants in ANGPTL4 and Risk of Coronary Artery DiseaseANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.Future Lipid-Altering Therapeutic Options Targeting Residual Cardiovascular Risk.ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice.Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases.Investigational therapies for hypercholesterolemia.Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D.ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.The iPSC Awakens ANGPTL3 in Tangier Disease.The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins.Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry.Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.Angiopoietin-like 3 in lipoprotein metabolism.ANGPTL3 serum concentration and rare genetic variants in Finnish population.Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice.Lomitapide for the treatment of hypercholesterolemia.Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites.Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation.Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3.
P2860
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P2860
ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
ANGPTL3 blockade with a human ...... dyslipidemic mice and monkeys.
@ast
ANGPTL3 blockade with a human ...... dyslipidemic mice and monkeys.
@en
type
label
ANGPTL3 blockade with a human ...... dyslipidemic mice and monkeys.
@ast
ANGPTL3 blockade with a human ...... dyslipidemic mice and monkeys.
@en
prefLabel
ANGPTL3 blockade with a human ...... dyslipidemic mice and monkeys.
@ast
ANGPTL3 blockade with a human ...... dyslipidemic mice and monkeys.
@en
P2093
P2860
P356
P1476
ANGPTL3 blockade with a human ...... dyslipidemic mice and monkeys
@en
P2093
Ashique Rafique
Corey A Alexa
David Buckler
David M Valenzuela
George D Yancopoulos
Helen H Hobbs
Ivory J Mintah
Jee Hae Kim
Jesper Gromada
Jonathan C Cohen
P2860
P304
P356
10.1194/JLR.M054890
P577
2015-05-11T00:00:00Z