Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling
about
Gap junctional regulation of signal transduction in bone cellsApoptotic osteocytes and the control of targeted bone resorptionConnexin 43 hemichannels and intracellular signaling in bone cellsPhysiological mechanisms and therapeutic potential of bone mechanosensing.Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging.Osteocyte-derived insulin-like growth factor I is not essential for the bone repletion response in miceInhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice.Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysisCx43 and mechanotransduction in bone.Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytesConnexins and pannexins in the skeleton: gap junctions, hemichannels and moreRole of connexins and pannexins during ontogeny, regeneration, and pathologies of boneDisuse rescues the age-impaired adaptive response to external loading in miceDefective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.Connexins in the skeletonRemoving or truncating connexin 43 in murine osteocytes alters cortical geometry, nanoscale morphology, and tissue mechanics in the tibia.Connexin43 modulates post-natal cortical bone modeling and mechano-responsiveness.Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load.The "connexin" between bone cells and skeletal functions.Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?The osteocyte plays multiple roles in bone remodeling and mineral homeostasis.Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling.Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation.Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading.Mechanosensitive miRNAs and Bone FormationCharacterisation of Bone Beneficial Components from Australian Wallaby Bone.Blockage of hemichannels alters gene expression in osteocytes in a high magneto-gravitational environment.Glucocorticoid Suppresses Connexin 43 Expression by Inhibiting the Akt/mTOR Signaling Pathway in Osteoblasts.Biological responses of osteocytic connexin 43 hemichannels to simulated microgravity.Joint diseases: from connexins to gap junctions.Roles of Irisin in the Linkage from Muscle to Bone During Mechanical Unloading in Mice.Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function.Cx43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice.
P2860
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P2860
Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Connexin 43 deficiency desensi ...... f both arms of bone remodeling
@ast
Connexin 43 deficiency desensi ...... f both arms of bone remodeling
@en
type
label
Connexin 43 deficiency desensi ...... f both arms of bone remodeling
@ast
Connexin 43 deficiency desensi ...... f both arms of bone remodeling
@en
prefLabel
Connexin 43 deficiency desensi ...... f both arms of bone remodeling
@ast
Connexin 43 deficiency desensi ...... f both arms of bone remodeling
@en
P2093
P2860
P1433
P1476
Connexin 43 deficiency desensi ...... f both arms of bone remodeling
@en
P2093
Alayna E Loiselle
Henry J Donahue
Shane A Lloyd
P2860
P356
10.1016/J.BONE.2013.07.022
P577
2013-07-24T00:00:00Z