The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.
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The hope for an HIV vaccine based on induction of CD8+ T lymphocytes--a reviewRole of HLA Adaptation in HIV EvolutionPeptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles.CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity.Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection.Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.T cell inactivation by poxviral B22 family proteins increases viral virulence.Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization.Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.T cell responses of HIV-infected children after administration of inactivated or live attenuated influenza vaccines.The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques.Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication.Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge.Cytotoxic capacity of SIV-specific CD8(+) T cells against primary autologous targets correlates with immune control in SIV-infected rhesus macaques.Diverse peptide presentation of rhesus macaque major histocompatibility complex class I Mamu-A 02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus.Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllers.The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques--implications for recombinant vaccine design.Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infectionCD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmissionThe majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages.Pirate primates in uncharted waters: lymphocyte transfers in unrelated, MHC-matched macaquesMamu-B*08-positive macaques control simian immunodeficiency virus replicationAssociation of MHC-I genotypes with disease progression in HIV/SIV infections.Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus.AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escapePol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation.Estimating the effectiveness of simian immunodeficiency virus-specific CD8+ T cells from the dynamics of viral immune escapeEvolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape.Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences.Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents.Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus.T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques.Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T CellsThe Mamu B 17-restricted SIV Nef IW9 to TW9 mutation abrogates correct epitope processing and presentation without loss of replicative fitness.
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The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The antiviral efficacy of simi ...... is abrogated by viral escape.
@ast
The antiviral efficacy of simi ...... is abrogated by viral escape.
@en
type
label
The antiviral efficacy of simi ...... is abrogated by viral escape.
@ast
The antiviral efficacy of simi ...... is abrogated by viral escape.
@en
prefLabel
The antiviral efficacy of simi ...... is abrogated by viral escape.
@ast
The antiviral efficacy of simi ...... is abrogated by viral escape.
@en
P2093
P2860
P50
P356
P1433
P1476
The antiviral efficacy of simi ...... is abrogated by viral escape.
@en
P2093
Benjamin J Burwitz
Denise S Rodrigues
Eva G Rakasz
Gnankang Napoé
Jason J Stephany
Jason Reed
Jessica Furlott
John T Loffredo
Juan Pablo Giraldo Vela
Kim L Weisgrau
P2860
P304
P356
10.1128/JVI.01912-06
P407
P577
2006-12-27T00:00:00Z