Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.
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SIV genome-wide pyrosequencing provides a comprehensive and unbiased view of variation within and outside CD8 T lymphocyte epitopesEx vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotypeTRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus MonkeysLoss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.Host HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naïve Ugandans.Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.Multi-low-dose mucosal simian immunodeficiency virus SIVmac239 challenge of cynomolgus macaques immunized with "hyperattenuated" SIV constructs.Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIV(mac251) challenge.Increased immunogenicity of HIV-1 p24 and gp120 following immunization with gp120/p24 fusion protein vaccine expressing alpha-gal epitopesTh17 cells and regulatory T cells in elite control over HIV and SIV.Maintenance or emergence of chronic phase secondary cytotoxic T lymphocyte responses after loss of acute phase immunodominant responses does not protect SIV-infected rhesus macaques from disease progression.Is an HIV vaccine possible?Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus.A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques.Linking pig-tailed macaque major histocompatibility complex class I haplotypes and cytotoxic T lymphocyte escape mutations in simian immunodeficiency virus infectionCytotoxic capacity of SIV-specific CD8(+) T cells against primary autologous targets correlates with immune control in SIV-infected rhesus macaques.Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escape.CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmissionSpecific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques.SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment.Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T CellsLytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses.Relevance of studying T cell responses in SIV-infected rhesus macaques.Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes.Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.HIV and HLA class I: an evolving relationshipHLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.Maintenance of AP-2 Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque.HIV control: Is getting there the same as staying there?
P2860
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P2860
Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Comprehensive immunological ev ...... irus-infected rhesus macaques.
@ast
Comprehensive immunological ev ...... irus-infected rhesus macaques.
@en
type
label
Comprehensive immunological ev ...... irus-infected rhesus macaques.
@ast
Comprehensive immunological ev ...... irus-infected rhesus macaques.
@en
prefLabel
Comprehensive immunological ev ...... irus-infected rhesus macaques.
@ast
Comprehensive immunological ev ...... irus-infected rhesus macaques.
@en
P2093
P2860
P50
P356
P1433
P1476
Comprehensive immunological ev ...... irus-infected rhesus macaques.
@en
P2093
Austin L Hughes
Chungwon Chung
Enrique J León
Gemma E May
Helen Piontkivska
Jessica Furlott
John Sidney
John T Loffredo
Nancy A Wilson
Nicholas J Maness
P2860
P304
P356
10.1128/JVI.00292-08
P407
P577
2008-04-02T00:00:00Z