Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene
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Methylation profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients.Clinical Neuropathology practice guide 5-2015: MGMT methylation pyrosequencing in glioblastoma: unresolved issues and open questionsTranscriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptationPromoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequenceTransfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agentsMethylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma responseAntineoplastic effect of decoy oligonucleotide derived from MGMT enhancer.Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene.Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cellsEpigenetic silencing of the MGMT gene in cancer.MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-statusSelf-destruction and tolerance in resistance of mammalian cells to alkylation damage.Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteinsAberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-like positioning.Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines.MGMT: a personal perspective.The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors.Expression of O(6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue.New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy.Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53.Influence of promoter/enhancer region haplotypes on MGMT transcriptional regulation: a potential biomarker for human sensitivity to alkylating agents.Progression of O⁶-methylguanine-DNA methyltransferase and temozolomide resistance in cancer research.Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300.The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas.Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts.Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells.Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.Increased sensitivity of transforming growth factor (TGF) beta 1 null cells to alkylating agents reveals a novel link between TGFbeta signaling and O(6)-methylguanine methyltransferase promoter hypermethylation.Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene.p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor.Glutathione S-transferase and O6-methylguanine DNA methyl transferase activities in patients with thyroid papillary carcinoma.MRI to MGMT: predicting methylation status in glioblastoma patients using convolutional recurrent neural networks.Repair gene O6 -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation.MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations.Inactivation of O6-methylguanine-DNA methyltransferase in human lung adenocarcinoma relates to high-grade histology and worse prognosis among smokers.Concordant association validates MGMT methylation and protein expression as favorable prognostic factors in glioma patients on alkylating chemotherapy (Temozolomide).Analysis for regulatory elements in yeastMGMTgene transcription
P2860
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P2860
Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Characterization of the promot ...... ine-DNA methyltransferase gene
@ast
Characterization of the promot ...... ine-DNA methyltransferase gene
@en
type
label
Characterization of the promot ...... ine-DNA methyltransferase gene
@ast
Characterization of the promot ...... ine-DNA methyltransferase gene
@en
prefLabel
Characterization of the promot ...... ine-DNA methyltransferase gene
@ast
Characterization of the promot ...... ine-DNA methyltransferase gene
@en
P2093
P2860
P356
P1476
Characterization of the promot ...... ine-DNA methyltransferase gene
@en
P2093
P2860
P304
P356
10.1093/NAR/19.22.6163
P407
P577
1991-11-01T00:00:00Z