Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

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http://www.wikidata.org/entity/Q40023435

Q40023435

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Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions Epigenetic mechanisms underlying the link between non-alcoholic fatty liver diseases and nutrition O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems Methylation matters Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research The future role of personalized medicine in the treatment of glioblastoma multiforme Methylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibility Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter Human DNA repair systems: an overview.Prognostic and predictive biomarkers: tools in personalized oncology.Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens.The pathobiology of glioma tumors Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrest Role of loss of o⁶-methylguanine dna methyltransferase (MGMT) expression in non-small cell lung carcinomas (NSCLCs): with reference to the relationship with p53 overexpression.Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide Methylation and colorectal cancer.A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas.O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy.Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.Flipping the epigenetic switch Genetic alterations of human brain tumors as molecular prognostic factors.Genetic pathways to primary and secondary glioblastoma Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma.Canadian recommendations for the treatment of glioblastoma multiforme.Epigenetic silencing of the MGMT gene in cancer.Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers.Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation.New (alternative) temozolomide regimens for the treatment of glioma.Association between response to primary treatments and MGMT status in glioblastoma.Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model Glioblastoma Multiforme Oncogenomics and Signaling Pathways.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.MGMT testing--the challenges for biomarker-based glioma treatment.Molecular prognostic factors in glioblastoma: state of the art and future challenges.

P2860

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P2860

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

Item

http://www.wikidata.org/entity/Q40023435

description

1997 nî lūn-bûn

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

@zh-hk

1997年論文

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1997年論文

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1997年论文

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1997年论文

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1997年论文

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name

Methylation of discrete region ...... ite and silencing of the gene.

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type

Item

label

Methylation of discrete region ...... ite and silencing of the gene.

@en

prefLabel

Methylation of discrete region ...... ite and silencing of the gene.

@en

P1476

Methylation of discrete region ...... ite and silencing of the gene.

@en

P2093

B W Futscher

http://www.w3.org/2001/XMLSchema#string

G S Watts

http://www.w3.org/2001/XMLSchema#string

J F Costello

http://www.w3.org/2001/XMLSchema#string

R O Pieper

http://www.w3.org/2001/XMLSchema#string

W S Dalton

http://www.w3.org/2001/XMLSchema#string

Y M Peng

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine

High sensitivity mapping of methylated cytosines

CpG islands in vertebrate genomes

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

Chromatin structure of transcriptionally competent and repressed genes

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene.

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

P304

5612-5619

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scholarly article

P356

10.1128/MCB.17.9.5612

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English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

1997-09-01T00:00:00Z

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P698

9271436

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P921

gene silencing

P932

232409

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Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

about

P2860

P2860

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P698

P921

P932