Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.
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Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a referenceO(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitionsEpigenetic mechanisms underlying the link between non-alcoholic fatty liver diseases and nutritionO(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problemsMethylation mattersInter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair researchThe future role of personalized medicine in the treatment of glioblastoma multiformeMethylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibilityPrognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastomaTranscriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoterHuman DNA repair systems: an overview.Prognostic and predictive biomarkers: tools in personalized oncology.Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens.The pathobiology of glioma tumorsProgressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrestRole of loss of o⁶-methylguanine dna methyltransferase (MGMT) expression in non-small cell lung carcinomas (NSCLCs): with reference to the relationship with p53 overexpression.Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomideMethylation and colorectal cancer.A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas.O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy.Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.Flipping the epigenetic switchGenetic alterations of human brain tumors as molecular prognostic factors.Genetic pathways to primary and secondary glioblastomaIntercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma.Canadian recommendations for the treatment of glioblastoma multiforme.Epigenetic silencing of the MGMT gene in cancer.Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers.Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers.Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation.New (alternative) temozolomide regimens for the treatment of glioma.Association between response to primary treatments and MGMT status in glioblastoma.Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft modelGlioblastoma Multiforme Oncogenomics and Signaling Pathways.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.MGMT testing--the challenges for biomarker-based glioma treatment.Molecular prognostic factors in glioblastoma: state of the art and future challenges.
P2860
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P2860
Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Methylation of discrete region ...... ite and silencing of the gene.
@en
type
label
Methylation of discrete region ...... ite and silencing of the gene.
@en
prefLabel
Methylation of discrete region ...... ite and silencing of the gene.
@en
P2093
P2860
P356
P1476
Methylation of discrete region ...... ite and silencing of the gene.
@en
P2093
B W Futscher
J F Costello
R O Pieper
W S Dalton
P2860
P304
P356
10.1128/MCB.17.9.5612
P407
P577
1997-09-01T00:00:00Z