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Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's diseaseIntracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's diseaseCharacterizing affinity epitopes between prion protein and β-amyloid using an epitope mapping immunoassayRAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunctionAluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque depositionHuman APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer modelThe Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motifFunctional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesisCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryThe toxicity of amyloid β oligomersOverview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal CompoundsMolecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision MedicineVascular aspects of cognitive impairment and dementiaDual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptideCaenorhabditis elegans as a model organism to study APP functionAlzheimer's pathogenesis and its link to the mitochondrionAlzheimer's disease--a panorama glimpseIntraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's diseaseAPP processing in Alzheimer's diseaseRegulation of distinct pools of amyloid β-protein by multiple cellular proteasesVitamin Supplementation as an Adjuvant Treatment for Alzheimer's DiseaseImmunotherapeutic approaches for Alzheimer's diseaseAnalyzing dendritic spine pathology in Alzheimer's disease: problems and opportunitiesDisruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid betaLack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivoElevation of cystatin C in susceptible neurons in Alzheimer's diseaseProtective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse modelsβ-amyloid triggers ALS-associated TDP-43 pathology in AD modelsMitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell deathOral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model.Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive declineMassive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic modelCognitive dysfunction and diabetes mellitusIntraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse modelSynaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterationsMechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Intraneuronal Abeta42 accumulation in human brain.
@ast
Intraneuronal Abeta42 accumulation in human brain.
@en
type
label
Intraneuronal Abeta42 accumulation in human brain.
@ast
Intraneuronal Abeta42 accumulation in human brain.
@en
prefLabel
Intraneuronal Abeta42 accumulation in human brain.
@ast
Intraneuronal Abeta42 accumulation in human brain.
@en
P2093
P2860
P50
P1476
Intraneuronal Abeta42 accumulation in human brain
@en
P2093
J P Greenfield
N R Relkin
V Haroutunian
P2860
P356
10.1016/S0002-9440(10)64700-1
P407
P577
2000-01-01T00:00:00Z