Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
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Lipid nanoparticles for targeted siRNA delivery - going from bench to bedsideIdentification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assayPhase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with advanced solid tumors.Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid FibroblastsIdentification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domainThe contributions of the European Medicines Agency and its pediatric committee to the fight against childhood leukemiaCotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate CancerUse of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytesVolasertib suppresses tumor growth and potentiates the activity of cisplatin in cervical cancer.Long noncoding RNA lnc-RI is a new regulator of mitosis via targeting miRNA-210-3p to release PLK1 mRNA activity.Targeting NEK2 as a promising therapeutic approach for cancer treatment.Volasertib suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.Strategies to optimize siRNA delivery to hepatocellular carcinoma cells.Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer.Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells.Plk1 inhibition enhances the efficacy of gemcitabine in human pancreatic cancer.Spotlight on Volasertib: Preclinical and Clinical Evaluation of a Promising Plk1 Inhibitor.Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics.Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinomaSilencing the roadblocks to effective triple-negative breast cancer treatments by siRNA nanoparticles.The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.Reduced kinase activity of polo kinase Cdc5 affects chromosome stability and DNA damage response in S. cerevisiae.Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.Identification of Polo-like kinases as potential novel drug targets for influenza A virus.Polo-like-kinase 1 is a proviral host-factor for hepatitis B virus replication.Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS.Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts.Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice.Decreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma.Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor.Polo-like kinase 3, hypoxic responses, and tumorigenesis.Plk1 inhibition leads to a failure of mitotic division during the first mitotic division in pig embryos.Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.Plk1 inhibition enhances the efficacy of BET epigenetic reader blockade in castration-resistant prostate cancer.Next generation sequencing of pancreatic ductal adenocarcinoma: right or wrong?Survival analysis of genome-wide profiles coupled with Connectivity Map database mining to identify potential therapeutic targets for cholangiocarcinomaEngineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor
P2860
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P2860
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
@ast
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
@en
type
label
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
@ast
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
@en
prefLabel
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
@ast
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
@en
P2860
P1476
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment
@en
P2093
Xiaoqi Liu
P2860
P304
P356
10.1016/J.TRANON.2015.03.010
P577
2015-06-01T00:00:00Z