Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic. - Wikidata - wikimedia - TriplyDB

Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic.

Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic.

http://www.wikidata.org/entity/Q35802862

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Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism Encephalitic alphaviruses Vaccinations for Neuroinfectious Disease: A Global Health Priority Dissecting the Role of E2 Protein Domains in Alphavirus Pathogenicity Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers Venezuelan equine encephalitis virus infection of mosquito cells requires acidification as well as mosquito homologs of the endocytic proteins Rab5 and Rab7 IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells Chimeric alphavirus vaccine candidates for chikungunya Vaccines for Venezuelan equine encephalitis Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells A chikungunya fever vaccine utilizing an insect-specific virus platform Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.Second generation inactivated eastern equine encephalitis virus vaccine candidates protect mice against a lethal aerosol challenge.Combined alphavirus replicon particle vaccine induces durable and cross-protective immune responses against equine encephalitis viruses Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses.Stability of RNA virus attenuation approaches IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution.Use of sindbis/eastern equine encephalitis chimeric viruses in plaque reduction neutralization tests for arboviral disease diagnostics Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus.Alphavirus production is inhibited in neurofibromin 1-deficient cells through activated RAS signalling.Arboviral encephalitides: transmission, emergence, and pathogenesis.Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription VIPR HMM: a hidden Markov model for detecting recombination with microbial detection microarrays Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice.CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus.RNA-based viral vectors.Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella The efficient packaging of Venezuelan equine encephalitis virus-specific RNAs into viral particles is determined by nsP1-3 synthesis.Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation.The 5'UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins.Analysis of human immunodeficiency virus type 1 vector cis- and trans-acting elements production by means of Semliki Forest virus.The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff.Changes of the secondary structure of the 5' end of the Sindbis virus genome inhibit virus growth in mosquito cells and lead to accumulation of adaptive mutations.

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P2860

Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic.

http://www.wikidata.org/entity/Q35802862

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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name

Recombinant sindbis/Venezuelan ...... ly attenuated and immunogenic.

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Recombinant sindbis/Venezuelan ...... ly attenuated and immunogenic.

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Recombinant sindbis/Venezuelan ...... ly attenuated and immunogenic.

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Recombinant sindbis/Venezuelan ...... ly attenuated and immunogenic.

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prefLabel

Recombinant sindbis/Venezuelan ...... ly attenuated and immunogenic.

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Recombinant sindbis/Venezuelan ...... ly attenuated and immunogenic.

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JVI.77.17.9278-9286.2003

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Journal of Virology

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Recombinant sindbis/Venezuelan ...... ly attenuated and immunogenic.

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P2093

Ivorlyne P Greene

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Michael Anishchenko

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Rafik Z Fayzulin

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Slobodan Paessler

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P2860

Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine.

Venezuelan equine encephalomyelitis in an adult animal host. An electron microscopic study

Chimeric Sindbis-Ross River viruses to study interactions between alphavirus nonstructural and structural regions

Recombinational history and molecular evolution of western equine encephalomyelitis complex alphaviruses

Translation of Sindbis virus mRNA: effects of sequences downstream of the initiating codon

Attenuation of Venezuelan equine encephalitis virus strain TC-83 is encoded by the 5'-noncoding region and the E2 envelope glycoprotein

Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs

In vitro mutagenesis of a full-length cDNA clone of Semliki Forest virus: the small 6,000-molecular-weight membrane protein modulates virus release

Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner

Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants

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9278-9286

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10615373

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