Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates.
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A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome.Slow modal gating of single G protein-activated K+ channels expressed in Xenopus oocytesMuscarinic K+ channel in the heart. Modal regulation by G protein beta gamma subunitsPhosphoinositides: tiny lipids with giant impact on cell regulationA Structural Determinant for the Control of PIP2 Sensitivity in G Protein-gated Inward Rectifier K+ ChannelsCrystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and SodiumX-ray structure of the mammalian GIRK2–βγ G-protein complexOsmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasisFunctional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteinsIdentification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimersGIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channelsRegulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase C-dependent mechanismsEicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site.Inhibition of acetylcholine-activated K(+) currents by U73122 is mediated by the inhibition of PIP(2)-channel interactionG-protein-coupled inwardly rectifying potassium channels are targets of alcohol actionSensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory painReceptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger.Synergistic activation of G protein-gated inwardly rectifying potassium channels by the betagamma subunits of G proteins and Na(+) and Mg(2+) ionsRegulation of Drosophila TRPL channels by immunophilin FKBP59.Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunitDepletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.What molecular events underlie heterologous desensitization? Focus on "receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors".G-protein mediated gating of inward-rectifier K+ channels.Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K+ channels in a receptor-specific mannerA genetically encoded tool kit for manipulating and monitoring membrane phosphatidylinositol 4,5-bisphosphate in intact cells.Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297.KATP channels gated by intracellular nucleotides and phospholipids.PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel.Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system.Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.Single channel analysis of the regulation of GIRK1/GIRK4 channels by protein phosphorylation.Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers.Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayersSpecificity of activation by phosphoinositides determines lipid regulation of Kir channels.N-terminal tyrosine residues within the potassium channel Kir3 modulate GTPase activity of Galphai.Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.Regulation of the muscarinic K+ channel by extracellular ATP through membrane phosphatidylinositol 4,5-bisphosphate in guinea-pig atrial myocytesNaringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.
P2860
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P2860
Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Activation of the atrial KACh ...... osphatidylinositol phosphates.
@ast
Activation of the atrial KACh ...... osphatidylinositol phosphates.
@en
type
label
Activation of the atrial KACh ...... osphatidylinositol phosphates.
@ast
Activation of the atrial KACh ...... osphatidylinositol phosphates.
@en
prefLabel
Activation of the atrial KACh ...... osphatidylinositol phosphates.
@ast
Activation of the atrial KACh ...... osphatidylinositol phosphates.
@en
P2093
P2860
P356
P1476
Activation of the atrial KACh ...... osphatidylinositol phosphates.
@en
P2093
D E Logothetis
J Petit-Jacques
P2860
P304
P356
10.1073/PNAS.95.3.1307
P407
P577
1998-02-01T00:00:00Z