Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.
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Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase CEicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site.Inhibition of acetylcholine-activated K(+) currents by U73122 is mediated by the inhibition of PIP(2)-channel interactionSignal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channelReceptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger.A genetically encoded tool kit for manipulating and monitoring membrane phosphatidylinositol 4,5-bisphosphate in intact cells.PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel.Vascular TRP channels: performing under pressure and going with the flowAgonist-induced localization of Gq-coupled receptors and G protein-gated inwardly rectifying K+ (GIRK) channels to caveolae determines receptor specificity of phosphatidylinositol 4,5-bisphosphate signaling.The complex and intriguing lives of PIP2 with ion channels and transporters.Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Functional M3 muscarinic acetylcholine receptors in mammalian heartsRegulation of the muscarinic K+ channel by extracellular ATP through membrane phosphatidylinositol 4,5-bisphosphate in guinea-pig atrial myocytesPasteurella multocida toxin interaction with host cells: entry and cellular effects.Pasteurella multocida toxin as a tool for studying Gq signal transduction.Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase CPhosphoinositide control of membrane protein function: a frontier led by studies on ion channels.Channelopathies linked to plasma membrane phosphoinositides.G protein-independent inhibition of GIRK current by adenosine in rat atrial myocytes overexpressing A1 receptors after adenovirus-mediated gene transfer.PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells.Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle.Overexpression of monomeric and multimeric GIRK4 subunits in rat atrial myocytes removes fast desensitization and reduces inward rectification of muscarinic K(+) current (I(K(ACh))). Evidence for functional homomeric GIRK4 channels.Short-term desensitization of muscarinic K+ current in the heart.Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its actionalpha-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes.Voltage-dependent open-channel block of G protein-gated inward-rectifying K(+) (GIRK) current in rat atrial myocytes by tamoxifen.Generation of a constitutive Na+-dependent inward-rectifier current in rat adult atrial myocytes by overexpression of Kir3.4.Overexpression of beta 1 and beta 2 adrenergic receptors in rat atrial myocytes. Differential coupling to G protein-gated inward rectifier K(+) channels via G(s) and G(i)/o.Acetylcholine-induced phosphatidylinositol 4,5-bisphosphate depletion does not cause short-term desensitization of G protein-gated inwardly rectifying K+ current in mouse atrial myocytes.Transfection of a phosphatidyl-4-phosphate 5-kinase gene into rat atrial myocytes removes inhibition of GIRK current by endothelin and alpha-adrenergic agonists.Properties and modulation of the G protein-coupled K+ channel in rat cerebellar granule neurons: ATP versus phosphatidylinositol 4,5-bisphosphate.Short-term desensitization of G-protein-activated, inwardly rectifying K+ (GIRK) currents in pyramidal neurons of rat neocortex.Regulation of cardiac IKs potassium current by membrane phosphatidylinositol 4,5-bisphosphate.Acute desensitization of GIRK current in rat atrial myocytes is related to K+ current flow.Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.Progesterone Protects Against Bisphenol A-Induced Arrhythmias in Female Rat Cardiac Myocytes via Rapid Signaling.Decrease in PIP(2) channel interactions is the final common mechanism involved in PKC- and arachidonic acid-mediated inhibitions of GABA(B)-activated K+ current.Dopamine D(2) receptor modulation of K(+) channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials.Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors.Role of receptor kinase in long-term desensitization of the cardiac muscarinic receptor-K+ channel system.
P2860
Q28344010-A64725BE-0DB6-4C71-BB3E-B21AB6E1B272Q28361626-1E3AA0CE-71A7-4100-949B-3A095DD55D75Q28362745-4D60D9BF-D458-474D-A62C-2394CF04C8E8Q28580081-D22A8E9A-3CB4-4638-BF92-F4EB72B061C2Q30307134-6FF83E20-49E0-4C85-8543-DB319BD83026Q33939724-A16B306D-F23F-4BD2-8D3F-0FBDD2CCB6E1Q34047720-74B16F3B-4CF3-4214-A844-5A3D511A2E9AQ34428913-6E478ABA-FBB7-44CF-BB10-28DF36E4F95FQ34438922-F6E63568-3E70-4FD3-87EE-32CC9DD36570Q34457658-587BE672-FA79-4324-BD23-A2DBD33E46F7Q34643934-2C5322D1-909B-4BD0-8553-8EB2E4F9A7A4Q35047149-F86A837D-89A8-4992-B786-141BA2BECF38Q35048874-DB56A317-0C70-4C21-AC32-4EC1747B84C9Q35534871-FF26F266-F6A4-4B40-A7C2-971F2704B2AFQ35568308-4308B2DE-64FA-49F1-B4BF-2B8919227BF9Q35732692-B5C2F694-0755-4120-8529-0DC987EEF4F6Q35799988-708A5791-00E8-4CF6-AD8D-BEB26273341EQ37732004-E0D5E61C-F5D7-476A-A2A7-7C5A90193951Q38353449-66452C39-3A80-4B77-80DE-CC6B745BF2D3Q40429831-6BF2B3E8-FA1D-4AEB-A12A-21B72BAB028BQ40579976-A2971F0C-85A3-4292-8C22-ECB0DB8F7BCBQ40802134-9766B152-9FD8-44D6-A257-9F9F79425537Q42094627-B3747B5C-2DD2-491D-B4CB-40B3253BD06EQ42156610-CF2C5851-CC9B-4193-A36E-9DF7BCCDC365Q42284029-0F3597A4-E7B5-410D-8F27-2BD9F547A9BEQ42514789-0EE04AF0-1D4C-43B8-9E53-0956300180BAQ42519144-6C0C0D58-5DD5-4D8D-8667-04336980541BQ43701650-3A0C4B01-D831-4BB7-AFD1-9573DB133D33Q43999090-8B29067A-A770-40C2-A7EE-5AC3DE7BE7CEQ44174080-E4843E7C-B87B-4C26-B61E-7CB9AA8CCFDFQ44478890-9F28CD88-62AF-425C-B92A-6DC571069F65Q44610958-3F901475-AF2D-42CB-A89D-61AE8A01A94DQ45057142-48988C96-3D63-4AF5-B423-6C575B3D546EQ45086579-BCB8D419-E919-4921-AFAB-58A1A0A9F977Q47448312-08A5E304-960C-4A39-9C19-F5E7F4400A41Q47821563-E5CE1827-2B2E-4F4C-BF3A-89C6BE0D6009Q48129558-11B92598-1E9A-4986-BEA7-5018E0FD5179Q48456185-E860F5D6-D720-4CB4-B0F3-C81C6E0B618FQ51760756-A907602E-E9A9-4729-BF36-486E2C575BCCQ52861366-F0517C91-DB4B-47C0-975C-FA8C2F63E4C1
P2860
Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.
description
2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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name
Depletion of phosphatidylinosi ...... K+ current in atrial myocytes.
@ast
Depletion of phosphatidylinosi ...... K+ current in atrial myocytes.
@en
type
label
Depletion of phosphatidylinosi ...... K+ current in atrial myocytes.
@ast
Depletion of phosphatidylinosi ...... K+ current in atrial myocytes.
@en
prefLabel
Depletion of phosphatidylinosi ...... K+ current in atrial myocytes.
@ast
Depletion of phosphatidylinosi ...... K+ current in atrial myocytes.
@en
P2093
P2860
P356
P1476
Depletion of phosphatidylinosi ...... K+ current in atrial myocytes
@en
P2093
Wellner-Kienitz MC
P2860
P304
P356
10.1074/JBC.M009179200
P407
P50
P577
2000-12-04T00:00:00Z