Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. - Wikidata - wikimedia - TriplyDB

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

http://www.wikidata.org/entity/Q35810077

about

Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway Epigenetic epidemiology: promises for public health research Implications of telomeres and telomerase in endometrial pathology Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9 Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole.Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma.Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling Role of p14(ARF) in replicative and induced senescence of human fibroblasts.Culture, immortalization, and characterization of human meibomian gland epithelial cells.Regulation of the human catalytic subunit of telomerase (hTERT).Novel strategies for immortalization of human hepatocytes.A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status Epstein-Barr virus immediate-early protein BZLF1 inhibits tumor necrosis factor alpha-induced signaling and apoptosis by downregulating tumor necrosis factor receptor 1 Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.Cooperation of hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: a cell transplantation model using bovine adrenocortical cells.Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells.Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions.Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture.Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras.Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes.Characterization of mre11 loss following HSV-1 infection.Development and validation of primary human myometrial cell culture models to study pregnancy and labour.Role of infectious agents in the carcinogenesis of brain and head and neck cancers.Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells.Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression.Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression.Genomic analysis of head and neck squamous cell carcinoma cell lines and human tumors: a rational approach to preclinical model selection.Non-telomeric activities of telomerase.On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscape.Telomere lengthening and other functions of telomerase.The Epstein-Barr virus immediate-early protein BZLF1 induces expression of E2F-1 and other proteins involved in cell cycle progression in primary keratinocytes and gastric carcinoma cells.Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions.In vitro model of stromal and epithelial immortalized endometriotic cells.Viral trans-factor independent replication of human papillomavirus genomes.Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.

P2860

Q24308746-DBAB8529-5397-4D0F-8010-CDFA846C0248 Q26864455-E219CE43-716D-4E2C-A429-CDC8DAF404FB Q28066490-74CEEC49-AEE6-4BED-A398-CFE814FDE117 Q28284628-1BBEFD06-CFB4-46C4-A7BB-B301518F625D Q30495595-D3B5C725-EED0-4185-8105-314BD424459A Q33598586-69804E33-0605-4D7A-8D63-20236CF5A8E8 Q33781678-E1B8B5D0-5A63-442F-8A08-50CC7D8AD4A6 Q34012414-47DBBD00-2328-4302-86E8-96FF91BB532F Q34022565-D0CFACDA-3903-44A2-B458-233E725EDB44 Q34180715-5F9B6F78-F762-43A8-AEDB-5FABA18B5DDC Q34329976-7CF164BF-7E5A-401E-8AE0-1BEEAA96838C Q34441492-7411AE1E-4C32-46C9-978D-B9F83F39F8D2 Q34553626-260AEDFC-D624-4BF6-9890-AECC34FA7428 Q34655822-D3FC0F82-AF71-4C02-AF6F-D029EFD14293 Q34775807-B9CCE883-F3A6-491C-BE4B-829C0BE501BB Q34883526-E59019F1-0364-42E5-ABD1-027D68FB3E98 Q35033316-01F22416-40F5-4A6B-9625-DFBF2C2F3283 Q35076939-20E7E743-F90C-441F-BA63-BD7551809804 Q35130666-383C11E3-D6E8-43D6-8FE0-E2561DC3C0AE Q35746972-66898C13-26BA-4A82-A935-CF6F73805F1E Q35791738-7A8404F4-E689-4F5F-A6F2-093C6C412F52 Q35846204-51174026-0D5E-4B45-BDF0-E45F1FDBF8EC Q36012702-6BD4AF33-3850-48C5-92F9-12E5F1C56A1B Q36063670-33E5DFA7-A372-406B-8B21-CA4AECC7CE6A Q36542446-27208073-EFB8-4539-8CB3-D5B4669C7AB0 Q36578508-6F28B59D-2639-4385-BFC3-9860D63CB5B9 Q36614198-49390429-59DB-4127-A46D-DF8CD0D5C067 Q36890676-32844EAE-AD90-490E-BF37-44024267626C Q37093515-2CB154F7-5274-4E9C-8A6A-9EE00FCD152D Q37564524-953729DD-A58B-4417-9CFF-EE7F9BAE1E3A Q37707102-DACCF739-12B2-4259-9936-5AF1443D3550 Q37833939-024F9CAD-13DB-4DD2-88B2-D98066AEF98D Q38020424-4FCDD82E-17FD-4DFB-AC11-9D1A4A3968AA Q38032836-776144D2-2127-4EFB-A5F5-B00DDC6220CA Q38360833-735A0C9B-BECB-4890-9A36-DCB0D5FCAA77 Q38835518-4AB1E682-B1D5-43DF-8053-6B847586C57E Q39438527-F4317D44-C5D1-48FA-8D15-9B09A6C8687E Q39694944-0BA9DE7D-1DC2-458E-9CEC-360040B52AE2 Q39843999-393EE7BB-1B4C-44E5-A81B-4368EDD6973C Q39958711-3BD80849-3924-4424-B482-1110318723CF

P2860

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

http://www.wikidata.org/entity/Q35810077

description

2000 nî lūn-bûn

@nan

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

2000年论文

@zh

2000年论文

@zh-cn

name

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

@ast

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

@en

type

label

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

@ast

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

@en

prefLabel

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

@ast

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

@en

P1433

Q35810077-7BCA6843-FEDC-4A5D-B656-2A9508381BB1

P1476

Q35810077-D5BB02EA-F4DF-44CF-86A3-2FC5162EB0E6

P2093

Q35810077-02367785-6ED7-4663-BA90-283014F91954

Q35810077-3E2F0938-856C-4B78-86B2-49DFA507EEEB

Q35810077-3E6FC851-F290-4C19-B3AE-C14560ADBFC4

Q35810077-60CB471F-C012-4884-BC4E-0E4EA64D4459

Q35810077-A5EFEBD4-E0AE-44FD-BC70-A3A8DF05877C

Q35810077-A9912AFA-6BB8-4520-B319-D22DB399D652

Q35810077-AB380F0B-AF8E-4470-B9BD-70AE2FFC4D60

Q35810077-EE2106C0-5D06-4F09-8597-61B37FFAA51A

Q35810077-F2AB9F04-EE5B-4681-8085-59B12AD80331

P2860

Q35810077-028E8836-A89D-4435-9D1D-FB0A85D90FC2

Q35810077-0737112B-ACBC-467B-99AA-DA6F1D605512

Q35810077-0A2DD3E6-05B3-475F-A5D6-BF076843A261

Q35810077-0E3DEE95-F0D8-455A-AF50-DF27ADC51AED

Q35810077-0F5EFE53-C6E7-4FC7-94AF-E3D3F2DA0795

Q35810077-0F94C120-798A-406D-B0DE-CA712F910ACB

Q35810077-15ABAF3A-8B32-46C3-BC72-047E04B7AF55

Q35810077-176F3609-81B9-4B43-A494-224E1EE62D6B

Q35810077-1D4EC15A-19C2-464B-90ED-25E731228B3B

Q35810077-21A549B3-7BC2-46ED-A332-E58D3F481C58

P304

Q35810077-CB7B8E1B-0582-4A0E-9F16-1EB28B6BC079

P31

Q35810077-6D49231C-D569-4DFD-A04F-8193A9045E43

P356

Q35810077-F1A7FD79-80B5-4D41-B79A-E99ACE604D15

P407

Q35810077-44F15A64-B00D-4D97-9E8B-F25D03AC42CE

P433

Q35810077-DAE95A0B-F0AD-471F-A314-48E69FFCDBD8

P478

Q35810077-5B433263-FE60-4FB4-9C4C-5A276D10CD9B

P577

Q35810077-F1314AE2-982D-4061-8483-0DF7885BE05C

P5875

Q35810077-ED88E938-1953-4F53-A10A-23604D088B28

P698

Q35810077-D0BA7848-BACC-4352-8C26-63EEA54A1AC3

P932

Q35810077-AB6FFA1D-A732-4BEA-9599-22B9BB320081

P356

S0002-9440(10)65025-0

P1433

The American Journal of Pathology

P1476

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase.

@en

P2093

A J Klingelhutz

http://www.w3.org/2001/XMLSchema#string

C P Matthews

http://www.w3.org/2001/XMLSchema#string

D G Farwell

http://www.w3.org/2001/XMLSchema#string

G A Bonnet

http://www.w3.org/2001/XMLSchema#string

G W Reuther

http://www.w3.org/2001/XMLSchema#string

J I Koop

http://www.w3.org/2001/XMLSchema#string

J K McDougall

http://www.w3.org/2001/XMLSchema#string

K A Shera

http://www.w3.org/2001/XMLSchema#string

M D Coltrera

http://www.w3.org/2001/XMLSchema#string

P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Extension of life-span by introduction of telomerase into normal human cells

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Genomic sequencing

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

Specific association of human telomerase activity with immortal cells and cancer

P304

1537-1547

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/S0002-9440(10)65025-0

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

156

http://www.w3.org/2001/XMLSchema#string

P577

2000-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

12524440

http://www.w3.org/2001/XMLSchema#string

P698

10793065

http://www.w3.org/2001/XMLSchema#string

P932

1876907

http://www.w3.org/2001/XMLSchema#string