Targeting Syk as a treatment for allergic and autoimmune disorders.
about
The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cellsMolecular mechanism of the Syk activation switchFunctional roles of Syk in macrophage-mediated inflammatory responsesTyrosine kinase inhibitors and mesenchymal stromal cells: effects on self-renewal, commitment and functionsAnaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infectionA Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint InflammationRegulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.Tyrosine kinases in inflammatory dermatologic disease.Deletion of Syk in neutrophils prevents immune complex arthritisSpleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis.Functional gastrointestinal disorders and mast cells: implications for therapy.Microsomal prostaglandin E synthase-1, ephrins, and ephrin kinases as suspected therapeutic targets in arthritis: exposed by "criminal profiling".Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studiesSyk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation.Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsivenessThe tyrosine kinase network regulating mast cell activation.Kinase inhibitors for the treatment of inflammatory and autoimmune disorders.Therapeutic prospect of Syk inhibitors.Pharmacokinetics, Pharmacodynamics, and Safety of Entospletinib, a Novel pSYK Inhibitor, Following Single and Multiple Oral Dosing in Healthy Volunteers.The discovery of novel experimental therapies for inflammatory arthritis.Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases.Targeting kinases for the treatment of inflammatory diseases.B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases.Kinase inhibitors: the next generation of therapies in the treatment of rheumatoid arthritis.Spleen tyrosine kinase inhibitors: a review of the patent literature 2010 - 2013.Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation.Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events.Inhibitory effect of the branches of Hovenia dulcis Thunb. and its constituent pinosylvin on the activities of IgE-mediated mast cells and passive cutaneous anaphylaxis in mice.The contribution of VEGF signalling to fostamatinib-induced blood pressure elevation.Homoisoflavanone prevents mast cell activation and allergic responses by inhibition of Syk signaling pathway.Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma.Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials.Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway.In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib.Development of a HTRF kinase assay for determination of Syk activity.Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey.Prevention of fostamatinib-induced blood pressure elevation by antihypertensive agents.Human spleen tyrosine kinase (Syk) recombinant expression systems for high-throughput assays.Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.
P2860
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P2860
Targeting Syk as a treatment for allergic and autoimmune disorders.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Targeting Syk as a treatment for allergic and autoimmune disorders.
@ast
Targeting Syk as a treatment for allergic and autoimmune disorders.
@en
type
label
Targeting Syk as a treatment for allergic and autoimmune disorders.
@ast
Targeting Syk as a treatment for allergic and autoimmune disorders.
@en
prefLabel
Targeting Syk as a treatment for allergic and autoimmune disorders.
@ast
Targeting Syk as a treatment for allergic and autoimmune disorders.
@en
P2093
P2860
P1476
Targeting Syk as a treatment for allergic and autoimmune disorders.
@en
P2093
Brian R Wong
Donald G Payan
Elliott B Grossbard
Esteban S Masuda
P2860
P304
P356
10.1517/13543784.13.7.743
P407
P577
2004-07-01T00:00:00Z