Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. - Wikidata - wikimedia - TriplyDB

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

http://www.wikidata.org/entity/Q35815863

about

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer Lactobacillus casei Zhang and vitamin K2 prevent intestinal tumorigenesis in mice via adiponectin-elevated different signaling pathways.Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production.Regulatory activities of transposable elements: from conflicts to benefits.AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy Mesenchymal stromal cells (MSCs) induce ex vivo proliferation and erythroid commitment of cord blood haematopoietic stem cells (CB-CD34+ cells).AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.Targeting inflammasome/IL-1 pathways for cancer immunotherapy.Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway.NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.Inflammasomes in Myeloid Cells: Warriors Within.Inflammasomes in Inflammation-Induced Cancer.The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease Genomic and transcriptomic heterogeneity of colorectal tumors arising in Lynch Syndrome.NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions.HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis.Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond.Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors.Inflammasome Complexes: Emerging Mechanisms and Effector Functions.The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry.Absent in melanoma 2 proteins in the development of cancer.Functions of interleukin-34 and its emerging association with rheumatoid arthritis.Microbiota as a mediator of cancer progression and therapy.AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway.Regulation of the gut microbiome by inflammasomes.Inflammasomes and Cancer.Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.Inflammasomes and intestinal inflammation.Mechanisms governing inflammasome activation, assembly and pyroptosis induction.Mechanisms regulating immune surveillance of cellular stress in cancer.Maturation-dependent expression of AIM2 in human B-cells.

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P2860

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

http://www.wikidata.org/entity/Q35815863

description

2015 nî lūn-bûn

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

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J.CELL.2015.06.001

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

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Daniel J McGoldrick

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David Finkelstein

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Deepika Sharma

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Gang Wu

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Geoffrey Neale

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Liqin Zhu

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Liyuan Li

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Qifan Zhu

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R K Subbarao Malireddi

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Richard J Gilbertson

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P2860

Phosphorylation of the PTEN tail regulates protein stability and function

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Crypt stem cells as the cells-of-origin of intestinal cancer

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Thirumala-Devi Kanneganti

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278962954

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26095253

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