Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis - Wikidata - wikimedia - TriplyDB

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

http://www.wikidata.org/entity/Q35819865

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Major Histocompatibility Complex I Expression by Motor Neurons and Its Implication in Amyotrophic Lateral Sclerosis Therapeutic neuroprotective agents for amyotrophic lateral sclerosis Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking The complex molecular biology of amyotrophic lateral sclerosis (ALS)The ubiquitin proteasome system in glia and its role in neurodegenerative diseases Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.Aging is not associated with proteasome impairment in UPS reporter mice.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Identification of nitric oxide as an endogenous inhibitor of 26S proteasomes in vascular endothelial cells.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution Protein quality control during erythropoiesis and hemoglobin synthesis Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot.Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT).Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.The biology of proteostasis in aging and disease.A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes mellitus.Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response Type I Vs. Type II Cytokine Levels as a Function of SOD1 G93A Mouse Amyotrophic Lateral Sclerosis Disease Progression.Rodent models of TDP-43: recent advances.Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.Inhibitors of the immunoproteasome: current status and future directions Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.Differential autophagy power in the spinal cord and muscle of transgenic ALS mice.Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part I, background and methods.Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS.Stressing the ubiquitin-proteasome system.Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent Neurofilamentopathy in neurodegenerative diseases Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.Protein recycling pathways in neurodegenerative diseases.A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans.UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia.

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Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

http://www.wikidata.org/entity/Q35819865

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2008 nî lūn-bûn

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Functional alterations of the ...... amyotrophic lateral sclerosis

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Human Molecular Genetics

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Functional alterations of the ...... amyotrophic lateral sclerosis

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Christa J Maynard

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Cristina Cheroni

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Elena Fontana

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Laura Vitellaro Zuccarello

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Marianna Marino

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Massimo Tortarolo

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Silvia De Biasi

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P2860

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

Amyotrophic lateral sclerosis

The 26S proteasome: a molecular machine designed for controlled proteolysis

Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.

Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis.

The proteasome.

The proteasome, a novel protease regulated by multiple mechanisms.

The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.

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82-96

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10.1093/HMG/DDN319

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1

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18

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Caterina Bendotti

Nico P. Dantuma

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2008-09-29T00:00:00Z

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23291653

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18826962

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amyotrophic lateral sclerosis

ubiquitin-proteasome system

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3298865

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