Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
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Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor ProgressionCRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.Immunodominant Dengue Virus-Specific CD8+ T Cell Responses Are Associated with a Memory PD-1+ Phenotype.Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.PD-1 expression conditions T cell avidity within an antigen-specific repertoire.CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease.Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survivalProgrammed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against AutoimmunityCD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent.TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potencyImmune Exhaustion and Transplantation.Basics of PD-1 in self-tolerance, infection, and cancer immunity.Genetic and Epigenetic Regulation of PD-1 ExpressionReversing T-cell Dysfunction and Exhaustion in Cancer.T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases.Metabolic programming in chronically stimulated T cells: Lessons from cancer and viral infections.T cell exhaustion: from pathophysiological basics to tumor immunotherapy.The Principles of Engineering Immune Cells to Treat Cancer.Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory.CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway.Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses.Molecular Dissection of CD8+ T-Cell Dysfunction.The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.BTLA identifies dysfunctional PD-1-expressing CD4+ T cells in human hepatocellular carcinoma.Multiple Inhibitory Pathways Contribute to Lung CD8+ T Cell Impairment and Protect against Immunopathology during Acute Viral Respiratory InfectionFunctional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells.PD-1 and PD-L1 expression in 132 recurrent nasopharyngeal carcinoma: the correlation with anemia and outcomes.The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer.B7-H1 Influences the Accumulation of Virus-Specific Tissue Resident Memory T Cells in the Central Nervous System.Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche.PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer.
P2860
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P2860
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Genetic absence of PD-1 promot ...... ntiated exhausted CD8+ T cells
@ast
Genetic absence of PD-1 promot ...... ntiated exhausted CD8+ T cells
@en
type
label
Genetic absence of PD-1 promot ...... ntiated exhausted CD8+ T cells
@ast
Genetic absence of PD-1 promot ...... ntiated exhausted CD8+ T cells
@en
prefLabel
Genetic absence of PD-1 promot ...... ntiated exhausted CD8+ T cells
@ast
Genetic absence of PD-1 promot ...... ntiated exhausted CD8+ T cells
@en
P2093
P2860
P356
P1476
Genetic absence of PD-1 promot ...... ntiated exhausted CD8+ T cells
@en
P2093
Arlene Sharpe
E John Wherry
Kristen E Pauken
Pamela M Odorizzi
P2860
P304
P356
10.1084/JEM.20142237
P407
P577
2015-06-01T00:00:00Z